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Biomedical subjects

D L Coffin

Publications and source records attributed to D L Coffin.

47 records · Page 3Linked to original sources
PubMed1969

Effects of nitrogen dioxide on pulmonary cell population.

Studies from this laboratory have shown that ozone produces changes in the number and function of cells obtained by pulmonary lavage. In similar experiments, rabbits exposed to levels of NO(2) from ambient to 60 ppm demonstrated increased numbers of polymorphonuclear leukocytes in the lung washings. This phenomenon persisted for more than 72 hr after a single 3-hr exposure. When streptococci were instilled in the lungs of NO(2)-exposed anesthetized rabbits 30 min before lavage, a pronounced inhibition of phagocytic activity was observed. With these criteria, NO(2) appeared less effective than ozone as a pulmonary irritant.

Air Pollution↗
PubMed1968

In vivo inactivation of lysozyme by ozone.

Bronchial mucus contains large quantities of the antibacterial enzyme lysozyme. Acutely exposing mice or rabbits to ozone reduced the amount of active lysozyme obtainable by bronchopulmonary lavage. The effect was proportional to ozone concentration, as well as to duration of exposure. Enzyme activity returned to normal levels during the 12 hr following exposure. Ozone (5 muliters/liter; 5 parts per million) for 3 hr reduced lysozyme levels approximately 30%. Studies of the release of lysozyme by alveolar cells support the theory that loss of activity is due to in vivo oxidation of lysozyme.

Air Pollution↗