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D L Crane

Publications and source records attributed to D L Crane.

8 recordsLinked to original sources
PubMed1990

Interferon induced inhibition of queuine uptake in cultured human fibroblasts.

Interferon inhibits uptake of the radiolabeled queuine analog, rQT3, into cultured human fibroblasts. Simultaneous exposure to 10 nM phorbol-12,13-didecanoate (PDD) potentiates interferon-induced inhibition of rQT3 into cultured fibroblasts. All three major classes of human interferon tested affected uptake similarly, with fibroblast derived beta-interferon being more effective in dose response than gamma or alpha interferons. This suggests that endogenous production of interferon by cultured cells, such as that observed during a low grade viral infection, inhibits queuine uptake and may subsequently lead to a decreased level of queuine modified transfer RNA. Queuine-hypomodified transfer RNA has been implicated in growth control, differentiation and neoplastic transformation.

Biological Transport↗
PubMed1990

Protein kinase C modulation of queuine uptake in cultured human fibroblasts.

Protein kinase C modulates the activity of a highly specific uptake mechanism for queuine in cultured human fibroblasts. Activators of protein kinase C induce an increased uptake rate for the radiolabeled analog of queuine, rQT3. The protein kinase C inhibitors, H-7, staurosporine and sphingosine all induced a dramatic decrease in the uptake rate of rQT3. This suggests that protein kinase C is tied to efficient cellular uptake of queuine. Uptake is prerequisite to the modification of transfer RNA with queuine. Perturbation of queuine-modified transfer RNA levels has been associated with neoplastic transformation, differentiation and growth control.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗
PubMed1990

Posts, points, and instruments: how to retrieve them, Part 1.

Retrieving metallic objects from teeth and canals produces anxiety, particularly if the dentist retrieving the object placed it there purposely, as in the case of a post, or inadvertently, as in the case of an accidental separation. Part I of this two-part series describes three methods that can be used to retrieve such objects. Case reports are used to exemplify each method. This series cannot turn the experience into an enjoyable one, but it will point out some ways to remove unwanted fragments from root canals.

Adult↗