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Biomedical subjects

D L Edbrooke

Publications and source records attributed to D L Edbrooke.

30 records · Page 2Linked to original sources
PubMed1983

Pharmacokinetics of etomidate associated with prolonged i.v. infusion.

Plasma concentrations of etomidate have been measured in six patients who required intermittent positive pressure ventilation following surgery. There was an approximately linear relationship between the plasma concentration and the rate of infusion of etomidate. The drug exhibited linear pharmacokinetics over a 10-fold variation in plasma concentration. The decrease in the plasma concentration after discontinuing the infusion was consistent with a three-compartment pharmacokinetic model. The plasma terminal half-life was found to be about 5.5 h, and the clearance calculated to be 0.025 litre kg-1 min-1.

Adolescent↗
PubMed1983

Use of etomidate in an intensive care unit.

A resumé of two studies and retrospective survey of 52 patients in an intensive care unit receiving infusions of etomidate has demonstrated that the technique can be used effectively and safely to provide sedation in patients requiring artificial ventilation and those breathing spontaneously. In both studies all measured respiratory and cardiovascular indices remained within normal limits. There was a low incidence of muscle movements in all groups and there was no nausea, vomiting, or allergic reactions. Additionally, the technique was readily accepted by the patients.

Adolescent↗
PubMed1982

Status asthmaticus. Management of status asthmaticus complicated by surgical emphysema--avoidance of intermittent positive pressure ventilation.

The management of a case of status asthmaticus complicated by surgical emphysema is described. In view of voice changes, intubation was necessary but intermittent positive pressure ventilation was considered unwise, because of the surgical emphysema. A means of maintaining adequate sedation in an intubated patient whilst allowing spontaneous respiration is outlined.

Adult↗
PubMed1982

Safer sedation for ventilated patients. A new application for etomidate.

A technique is described for sedation of ventilated patients. Six patients who underwent major maxillofacial surgery were given low dose infusions of etomidate and fentanyl for postoperative sedation. Measurements of respiratory function were recorded before and during the period of intermittent positive pressure ventilation. Plasma etomidate levels were estimated. After initial stabilisation on almost constant rate of infusion was used to provide a reproducible level of sedation from which the patients were easily aroused. All patients maintained an adequate minute volume when disconnected from the ventilator. All measured and derived respiratory indices remained within normal limits. Patients exhibited amnesia throughout the period of infusion. All patients found this method of sedation pleasant. This technique may be recommended as an alternative to conventional methods of sedation for ventilated patients.

Adolescent↗
PubMed1979

Laminar flow enclosure-a possible risk to the patient.

A retrospective comparison was made between two groups of 50 adult patients who underwent open-heart surgery in an operating suite with two adjacent rooms, one of which was equipped with a laminar flow enclosure. Core and body surface temperatures were measured at 15-min intervals for the 1st h after commencement of surgery. Patients in a laminar flow enclosure showed a significantly greater decrease in core temperature with time. Possible means of counteracting this are suggested.

Adult↗
PubMedDate not supplied

Clinical applications of electrical impedance tomography.

This article is a preliminary review of the possible clinical applications of electrical impedance tomography (EIT). The applications to, for example, the central nervous, respiratory, cardiovascular and digestive systems are covered. It is concluded that the area of greatest potential application of EIT is monitoring cardiopulmonary function, but that studies on much larger groups of patients than have been carried out hitherto are required to fully assess the potential of EIT as a clinical tool.

Body Composition↗