Biomedical subjects
Publications and source records attributed to D L Kirkpatrick.
Quality Assurance, (QA), is an expanding hospital-based system of optimizing cost-effective eye care. It seeks to minimize patient care problems. Drawing from military experience with QA under the JCAH, a QA checklist and a patient satisfaction survey are presented as tools to improve QA programs for other optometrists.
4-Dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen 3-one hydrochloride (II) was shown to stimulate respiration in rat liver mitochondria at levels of 2.5 mumoles or less; but at levels higher than 5.0 mumoles, respiration was inhibited when succinate and 3-hydroxybutyrate were the substrates. Compound II caused inhibition of respiration in the presence of glutamate over the dose range studied. The stimulating effect of II was attributed to its functioning as an uncoupling agent. Its inhibiting properties were considered to be due to its behaving like antimycin A in blocking transport of electrons between cytochromes b and c1. The effect of II on respiration in mitochondria varied with the pH of the medium. A conjugated styryl ketone, which contained a nuclear hydroxy function and was structurally related to II, also stimulated respiration at low doses while inhibiting respiration at higher concentrations. Etherification of the hydroxy group led to compounds in which only stimulation of respiration was noted.
A number of analogs of a new antineoplastic agent, 1-(m-ethoxymethyloxyphenyl)-1-nonen-3-one (IIIa) were prepared and evaluated against murine P-388 lymphocytic leukemia. Metabolic studies of IIIa in rats showed that it was sequestered rapidly to the brain and hence probably to other adipose tissue, which may account for the absence of IIIa and metabolites in urine and feces. A detailed toxicological evaluation of IIIa in rats showed marked pathological changes principally in the liver and spleen as a result of erythrophagocytosis from bleeding into the abdomen.
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