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Biomedical subjects

D L Klein

Publications and source records attributed to D L Klein.

41 records · Page 3Linked to original sources

Metastasizing plasma cell tumor of the small bowel.

An 81-year old man who had a plasmacytoma of the ileum presented with melena for which no bleeding site could be established before surgery. He developed intussusception and the tumor was located at laparotomy. Metastases to the skin and axillary lymph nodes were documented prior to his operation, to mesenteric lymph nodes at surgery and to intrathoracic lymph nodes and a substernal goiter at autopsy. The liver, spleen, bones and marrow were not involved by myeloma or amyloid. Immunoelectrophoresis demonstrated an Ig-A (lambda) monoclonal protein in the serum (with nondiagnostic serum zone electrophoresis patterns) and lambda light chains in the urine. Immunoflourescense of Ig-A (lambda) globulin was present in imprint preparations from the bowel tumor.

Aged↗

Accelerated atherosclerosis during maintenance hemodialysis: detection from chest radiographs.

Evidence of accelerated atherosclerosis was studied from chest radiographs of 26 patients on maintenance hemodialysis. The aortic knob was observed for presence of and increase in calcified plaques. At the initiation of hemodialysis, the degree of aortic calcification was no different from that seen in the control group. After periods ranging from one and a half to eight years, the patients on hemodialysis showed a significantly greater amount of aortic calcification and a significantly higher rate of calcification. The degree of calcification correlated with the severity of cardiovascular disease as determined clinically. For patients on maintenance hemodialysis, close scrutiny of serial chest-radiographs may help to identify those who are at greater risk for life-threatening cardiovascular disease.

Adult↗