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Biomedical subjects

D L Page

Publications and source records attributed to D L Page.

At least 253 records · Page 14Linked to original sources
PubMed1975

Effect of blood flow rate on subendothelial proliferation in venous autografts used as arterial substitutes.

The effect of augmented and reduced blood flow rates through autogenous vein grafts (AVG) on the histological characteristics of veins used for arterial substitutes was studied in 22 dogs. In each animal autogenous jugular veins were implanted as conduits to replace excised segments of both iliac arteries. In one group (control) blood flow through the AVG conduits was not modified, but in the remaining animals blood flow rate was either augmented by a distal femoral arteriovenous fistula or reduced by a distal arterial stenosis. In the control group in which there was no modification of blood flow, subendothelial proliferative lesions (SEPL) were found in the vein graft, and typical SEPL were found at each anastomosis. However, in those animals in which blood flow was reduced by an average of 44% through the graft, SEPL were more numerous throughout the length of the vein graft, and the anastomotic SEPL were more prominent. In contrast, those animals in which a unilateral distal arteriovenous fistula augmented blood flow through the AVG (average 6.7-fold increase), no SEPL were detected along the length of the graft. Although SEPL were present at the suture lines, the lesions were much less prominent. These findings suggest that the magnitude and distribution of SEPL in AVG are determined, in part, by the rate of blood flow through the graft.

Animals↗
PubMed1974

Pheochromocytoma.

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Adrenal Gland Neoplasms↗
PubMed1973

Structural identity of Bence Jones and amyloid fibril proteins in a patient with plasma cell dyscrasia and amyloidosis.

The partial amino acid sequence of the amyloid fibril protein isolated from the small intestine of a patient with plasma cell dyscrasia and associated amyloidosis has been determined and compared with the sequence of the kappa-type Bence Jones protein isolated from the urine of the same patient. Identical sequences were observed for the 27 amino-terminal residues that could be compared. The C-terminal tryptic peptide of the amyloid protein was identical with that of the Bence Jones protein. Apparent molecular weights and amino acid compositions of the Bence Jones and amyloid proteins were similar. It appears, therefore, that the predominant protein present in the amyloid deposits in this patient was an intact kappa-type light polypeptide chain that was identical with the urinary Bence Jones protein.

Amino Acid Sequence↗
PubMed1973

Amyloid nephropathy of Ostertag with special reference to renal glomerular giant cells.

The pathology of an unusual form of nonneuropathic familial amyloidosis is presented. The disease, occurring in two sisters, is similar to a form of familial amyloidosis described by Ostertag in 1950 and is characterized by progressive renal failure and an autosomal dominant mode of inheritance. Widespread vascular amyloidosis and dense renal glomerular amyloid deposits characterize the disease pathologically. Renal interstitial foam cells and glomerular giant cells were found in the kidneys of one sister. The giant cells, probably of macrophage origin, contain amyloid fibrils within poorly formed non-membrane-bounded cytoplasmic vacuoles. Transitions to well-formed membrane-bounded cytoplasmic vacuoles with nonfibrillar material were also present. It is suggested that these cells function to degrade and resorb amyloid, and that as amyloid is changed to a nonfibrillar state, well-defined membranes can form around the degraded material.

Amyloid↗
PubMed1972

Social interaction and wounding in the genesis of "spontaneous" murine amyloidosis.

Seven strains of mice were closely observed during the development of amyloidosis in the absence of experimental manipulation except for alteration in group and cage sizes. Amyloid development was greatest in the strains showing the most evident effects of wounding from fighting activity. In groups fighting extensively, up to a 100% incidence of generalized amyloidosis was reached in submissive mice. Groups of female mice did not fight and only developed amyloidosis in association with infection. The occurrence of amyloidosis correlates with the chronic anemia and splenomegaly long known to attend submissive social standing within groups of male mice. Dominant mice were uniformly spared wounding, anemia, splenomegaly and amyloidosis as were singly caged mice. Amyloidosis appearing in the absence of experimental manipulation is a sequel of social submissiveness and consequent wounds.

Aggression↗
PubMed1971

Creation of "amyloid" fibrils from Bence Jones proteins in vitro.

"Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, beta-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested.

Amino Acid Sequence↗