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D L Ranson

Publications and source records attributed to D L Ranson.

24 records · Page 2Linked to original sources
PubMed1986

Burkitt-like lymphoma in an English child: characterisation of tumour biopsy cells and of the derived tumour cell line.

An eight year old English boy presented with an abdominal undifferentiated 'Burkitt-like' lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African 'endemic' Burkitt's lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was indistinguishable from that previously shown by biopsies of EBNA positive endemic BLs. It therefore appears that both the endemic and sporadic forms of BL, as illustrated by this case, may be derived from the same subset of progenitor cells.

Abdominal Neoplasms↗
PubMed1986

Comparison of the results of asbestos fibre dust counts in lung tissue obtained by analytical electron microscopy and light microscopy.

The efficiency of the light microscope with that of the electron microscope in detecting asbestos fibres in human lung tissue was computed. Necropsy material from 55 patients who had died from asbestos related diseases was analysed independently by phase contrast microscopy and electron microscopy. As expected the number of fibres identified using electron microscopy was higher than that identified by light microscopy. By adjusting the electron allow for the limited resolving power of the light microscope, however, a significant correlation of the number of fibres identified using the two methods was obtained. The best correlation was found with specimens containing crocidolite (correlation coefficient 0.79) and amosite (correlation coefficient 0.74), while chrysotile gave a much lower correlation (correlation coefficient 0.15). The cumulated fibre diameter distribution obtained using the electron microscope suggests that the light microscope is able to visualise only 5% of crocidolite, 26.5% of amosite, and 0.14% of chrysotile present in lung tissue. Therefore, although it is possible, using the electron microscope, to predict the asbestos fibre count that would be obtained by light microscopy, the reserve prediction cannot be made: it is impossible to determine the proportion of the various asbestos mineral types using the light microscope.

Asbestos↗
PubMed1985

Peculiarities of mucinous colorectal carcinoma.

The clinical and pathological features of 54 mucinous carcinomas of the large intestine were compared with those of 576 non-mucinous carcinomas. Tumours were only categorized as mucinous if they contained at least 60 per cent of mucin by volume. Those with a moderate mucin content (60-80 per cent) were indistinguishable in behaviour from 'non-mucinous' tumours. By contrast, those with a high mucin content (greater than 80 per cent) showed several differences from non-mucinous cancers: they had a more proximal distribution through the large intestine, they comprised a greater fraction of cancers in the under 50 age group (24 versus 7 per cent: P less than 0.01), they were more likely to be Dukes' stage 'D' (58 versus 31 per cent: P less than 0.01) and local fixity was commoner (70 versus 37 per cent: P less than 0.001). Consequently the overall resection rate was reduced from 90 to 73 per cent (P less than 0.01), the curative resection rate from 69 to 42 per cent (P less than 0.01) and the 5-year survival rate from 37 to 18 per cent (P less than 0.05). Colorectal carcinomas of high mucin content require wide excision, tend to recur locally and carry a poor prognosis.

Adenocarcinoma↗
PubMed1984

Metastasis to the larynx from a prostatic carcinoma. A case report.

We present the fourth reported case of metastases of adenocarcinoma from the prostate to the larynx. The patient was a 64-year-old male who presented with stridor from a smooth subglottic mass six months after he had been diagnosed as having adenocarcinoma of the prostate with bone secondaries. We have reviewed the mechanisms by which such a tumour might metastasize to the larynx and we feel that ossification in the laryngeal cartilages may be important in the development of such metastases.

Adenocarcinoma↗