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Biomedical subjects

D L Roper

Publications and source records attributed to D L Roper.

8 recordsLinked to original sources

Applanation tonometry with and without fluorescein.

Some investigators have suggested that it is not necessary to be fluorescein when doing applanation tonometry. This is incorrect because, in order to visualize the apex of the tear order to visualize the apex of the tear meniscus which defines the applanated area, the tears must be stained with fluorescein. I found an average pressure of 11.72 +/- 3.20 mm Hg in eyes tested without fluorescein compared with an average pressure of 17.34 +/- 4.07 mm Hg when pressures were immediately remeasured with fluorescein. Failure to use fluorescein during applanation tonometry will result in an under-estimation of approximately 5.62 mm Hg.

False Negative Reactions↗

Corneal ulceration secondary to intestinal Shigella sonnei.

A 34-month-old boy had a corneal ulcer due to Shigella sonnei. To my knowledge, this is the first documented case reported where the same organism was recovered from the stool. One other case of S sonnei and two cases of S flexneri corneal ulcers have appeared in the literature. All cases have been in young black boys between the ages of 23 months and 6 years. The exact pathogenesis remains unclear, but direct fecalocular inoculation into a preexisting epithelial defect, a probable herpetic dendrite in this case, is most likely.

Ampicillin↗

Effect of hyaluronidase on the incidence of cystoid macular edema.

A prospective double-blind study of the effect of hyaluronidase on aphakic cystoid macular edema (CME) was performed. A 25% incidence of CME was encountered in patients receiving hyaluronidase admixed with the local anesthetic while no cases were diagnosed in the group not receiving hyaluronidase. The role of hyaluronidase in the pathogenesis of aphakic cystoid macular edema is discussed.

Acetylcholine↗

Borderline melanocytic tumor of the conjunctiva: diagnostic and therapeutic considerations.

A clinically benign appearing nevus was surgically excised from the conjunctiva of a 13-year-old girl because of complaints that it had recently enlarged. Histologically, the melanocytic lesion displayed considerable cytologic atypia and showed signs that were consistent with malignant transformation. Because of the rarity of conjunctival melanomas in children, the case was reviewed by several experienced pathologists and dermatopathologists whose diagnoses ranged from benign nevus with atypia to malignant melanoma. When the biologic potential of certain melanocytic lesions cannot be accurately predicted histologically, treatment and follow up must be individualized. Physicians must weigh the perceived risks and disadvantages of treating a histologically indeterminate tumor against the consequences of "under" treatment if the lesion is, in fact, biologically malignant.

Adolescent↗