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Biomedical subjects

D L Roth

Publications and source records attributed to D L Roth.

47 records · Page 3Linked to original sources
PubMed1985

Activity-related changes in protein phosphorylation in an identified Aplysia neuron.

The relationship between long-term electrical activity and protein phosphorylation was investigated in single, identifiable neurons in the abdominal ganglion of Aplysia californica by the intracellular injection of radiolabeled ATP followed by sodium dodecyl sulfate (SDS) gel electrophoresis. Natural and pharmacological treatments that alter the impulse activity of neurons L6 and R15 for prolonged periods did not appear to affect the phosphorylation of most of the 15 major phosphoproteins examined in these cells. Long-term excitation of L6 induced by the phosphodiesterase inhibitor IBMX correlated with phosphorylation of a 29,000-dalton protein. Long-term inhibition of L6 induced by afterdischarge of peptidergic bag-cell neurons appeared to cause dephosphorylation of a 29,000-dalton protein. Burst augmentation of R15 induced by bag-cell afterdischarge did not cause detectable changes in the phosphorylation of the major proteins we examined. These data are consistent with other studies of neural and nonneural tissues which have found a correlation between activity and the level of phosphorylation of a 29,000-dalton protein.

1-Methyl-3-isobutylxanthine↗
PubMed1985

Factors in the self-deception questionnaire: associations with depression.

Disagreement presently exists over whether depressed or nondepressed persons exercise more cognitive distortion on material about the self. A negative correlation between the Self-Deception Questionnaire (SDQ, Sackeim & Gur, 1978, 1979) and the Beck Depression Inventory (BDI, Beck, 1967) has been cited as evidence that it is the nondepressed individuals who exercise more distortion (Sackeim, 1983). This negative correlation was replicated, and the SDQ was factor analyzed to determine which factors might account for the correlation with depression. The three largest factors, identified by content themes of relationships with parents, emotionality, and denial of tabooed activities, correlated reliably with the BDI. Discussion focused on whether these correlations reflect differences in self-deception that are associated with depression or differences in veridical responding between depressed and nondepressed subjects on those items in the SDQ. Suggestions for future research and possible therapeutic implications are also discussed.

Cognition↗
PubMed1985

Regional changes in EEG power and coherence during cognition: intensive study of two individuals.

Two men underwent weekly electroencephalogram (EEG) recordings while living for several months in a controlled laboratory environment. Data collected from an eight-channel EEG during a resting period and during performance of two cognitive tasks (word fluency and mental imagery) were subjected to spectral analysis. Statistical analyses on power and coherence were conducted for each subject separately, to determine whether that individual showed a characteristic pattern of EEG activity for a given cognitive task which was stable over time. Although substantial individual differences were observed, particularly for the theta band, both subjects showed changes in the spectral information over the anterior left hemisphere during the word fluency task.

Cerebral Cortex↗
PubMedDate not supplied

Influence of physical fitness in determining the impact of stressful life events on physical and psychologic health.

To determine whether physical fitness (aerobic capacity) moderated the relationship between stressful life events and subsequent illness, 112 subjects first reported their life changes (stress) for the preceeding 12 months and then had their fitness assessed with a submaximal bicycle ergometer test. For the next 9 weeks, the subjects kept records concerning their physical health (e.g., ailments, doctor visits, medication usage), and at the end of that period they completed forms that measured psychologic symptoms (e.g., depression, anxiety, alienation). Multiple regression analyses revealed that a high level of life stress during the preceding year was related to poorer subsequent physical health for subjects with a low level of fitness in particular. Life stress was found to have little impact on the subsequent physical health of fit subjects. Similar results were found for depression. These results indicate that fitness does moderate the stress-illness relationship and suggest that increasing fitness may be a way of diminishing the effects of unavoidable stress.

Adolescent↗
PubMedDate not supplied

Influence of aerobic exercise training and relaxation training on physical and psychologic health following stressful life events.

An experiment was conducted to determine whether aerobic exercise training or relaxation training would be effective for reducing the deleterious effects of life stress on physical and psychologic health. Over 1000 college students were surveyed, and 55 of those who reported experiencing a high number of negative life events over the preceding year were assigned to an aerobic exercise training condition, a relaxation training condition, or a no-treatment control condition. Physical and psychologic health were assessed with self-report measures before, halfway through, immediately following, and 8 weeks after the 11-week training (and control) period. Heart rate data collected during a treadmill test indicated that the aerobic exercise training was effective for improving cardiovascular fitness. Psychologic measures indicated that the exercise training condition was more effective than the other two conditions for reducing depression during the first 5 weeks of training. No differences were found among the conditions on self-report measures of physical health. These findings suggest that aerobic exercise training may be useful for reducing the severity and duration of depressive reactions following stressful life change.

Adaptation, Psychological↗
PubMedDate not supplied

The effects of aerobic exercise on cardiovascular, facial EMG, and self-report responses to emotional imagery.

This study examined the effects of exercise on subsequent psychophysiological and self-report responses to emotional imagery, using excitation-transfer theory as a guiding conceptual model. Twenty-four female undergraduates engaged in aerobic exercise (stationary cycling) for 15 minutes, and an equal number of subjects rested quietly for the same time period. All subjects then engaged in anger and sadness imagery trials. Cardiovascular, facial electromyographic, and self-report responses to the imagery were assessed. The results indicated that the subjects in the exercise group showed less peripheral vasoconstriction in response to the imagery than did the quiet rest subjects. Subjects in both groups displayed greater electromyographic activity in the depressor and zygomatic muscle regions during anger than sadness imagery, and subjects in the exercise group tended to show greater corrugator tension during sadness than during anger imagery. Few differences between the groups were found on self-report measures. These findings are discussed with reference to previous research, theoretical implications, and future directions.

Adult↗
PubMedDate not supplied

Physical exercise, stressful life experience, and depression in adults with epilepsy.

Adults with epilepsy completed self-report measures of exercise participation, barriers to exercise, stressful life experience, depression, and general psychosocial adjustment (n = 133) as part of routine outpatient visits. Descriptive statistics showed lower levels of depression among patients who exercised regularly. Structural equation analyses confirmed the fit of a path model that included significant direct effects of exercise and stressful life experience on depression. These effects were independent of each other, and independent of the influence of other predictor variables, such as seizure frequency, age, and gender. Stressful life experience also had a direct unique effect on seizure frequency in the multivariate models. These results suggest that problems with depression, which are common in adults with epilepsy, are significantly lower among those who exercise regularly and avoid stressful life change.

Adolescent↗