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Biomedical subjects

D L Tai

Publications and source records attributed to D L Tai.

6 recordsLinked to original sources
PubMed1985

Interstitial radiation implantation for unresectable nonoat cell carcinoma of the lung. Techniques and preliminary results.

The majority of lung cancers are unresectable at diagnosis. The radiation tolerance of the surrounding spinal cord and heart limits the external radiation therapy dose. Interstitial radiation implantation was utilized to deliver higher radiation dose, sparing the surrounding normal tissues in patients with unresectable nonoat cell cancers of the lung less than 8 cm in diameter localized to the thorax with no associated pleural effusion. The methods of implantation included permanent interstitial iodine-125 implantation of the gross disease in the lung and/or lymph nodes delivering about 120 Gy (12,000 rads) in 1 year and removable iridium-192 interstitial implantation of residual disease in the mediastinum, chest wall, or margin or resection in the lung, delivering about 30 Gy (3000 rads) in three days. Supplementary external radiation therapy of 40 Gy (4000 rads) in 4 weeks is delivered 4-6 weeks after implantation. The interstitial implant procedure adds only about 45 minutes to 1 hour to the operating time, and converts a palliative procedure into a potentially curative treatment. This article presents our experience with 11 cases, with early short-term follow-up results, and is designed to stimulate others to evaluate a similar approach to improve local control and survival in unresectable lung cancers.

Adenocarcinoma↗
PubMed1984

Biliary tract neoplasms: a simple management technique.

This paper presents a simple, fast, and accurate afterloading method of delivering high radiation dose to tumors of the biliary tract, using radioactive iridium through a biliary drainage catheter. A Tuohy Borst sidearm adaptor permits concurrent drainage. The dose delivered in this manner can be used to supplement the palliative external beam radiotherapy, with minimal side effect.

Adult↗
PubMed1983

Carcinoma of the female urethra: reassessment of modes of therapy.

Of 15 women with primary urethral carcinoma 2 had tumors confined to the urethra and were managed successfully by an operation. Of the 9 patients with tumor extending to the surrounding structures 6 (67 per cent) died of complications related to inadequate control of the primary tumor. The last 4 patients had stage D1 disease or greater at initial diagnosis and died of distant metastases. Our current approach for patients with locally advanced disease is combined brachytherapy and operation in an effort to eradicate the primary tumor, since morbidity and mortality result from failure to control the local tumor.

Adenocarcinoma↗
PubMedDate not supplied

Neutron and gamma dose distribution for tandem, tandem and ovoid and plaque for intracavitary 252Cf therapy of cervix carcinoma.

252Cf was used to treat tumors of the cervix in an ongoing clinical trial. Tandem and ovoids were used as well as a combination of single and multiple applications. Dosimetric analysis of these treated cases revealed the patterns of neutron dose rate and neutron/gamma ray dose ratios which were achievable using a variety of loading arrangements. Although pelvic tumor reference points and tissue dose was in general similar whether a tandem or tandem plus ovoids were used, vaginal dose was increased over two-fold or more by the use of vaginal applicators and sources. This indicates that a variety of individualized arrangements for different clinical presentations can be used for brachytherapy of gynecological pelvic neoplasm.

Brachytherapy↗