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Biomedical subjects

D Labayle

Publications and source records attributed to D Labayle.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Sclerosing cholangitis, chronic pancreatitis and Sjögren's syndrome].

A 63 year old man was followed up for chronic pancreatitis. After 2 years, he developed features of primary sclerosing cholangitis associated with Sjögren's syndrome. A review of the literature revealed 38 previous cases of chronic pancreatitis associated with sclerosing cholangitis; a sicca complex was also demonstrated in 3 of these cases. Chronic pancreatitis is mostly asymptomatic and the diagnosis is usually made at laparotomy or postmortem. Retrograde pancreatograms are abnormal in 15-75 p. 100 of patients with primary sclerosing cholangitis. The relationship between the two diseases is not a coincidence. On the other hand, the significance of the association with the Sjögren's syndrome remains controversial.

Cholangitis↗
PubMed1984

[Chronic alcoholic pancreatitis: relation of pain to withdrawal and pancreatic surgery].

A group of 73 patients suffering from painful alcoholic, chronic pancreatitis, hospitalized from 1971 to 1981, has been analyzed retrospectively. The aim was to assess the effects of alcohol withdrawal and pancreatic surgery on the course of pancreatic pain. The mean number of years during which the patients complained of pain was 3.5 +/- 0.5 (m +/- SEM). At the end of follow-up, 70 p. 100 of the patients did no longer suffer, alcohol withdrawal was obtained in 45 p. 100 and surgery had been performed in 41 p. 100. Continued alcohol abuse did not prevent pain relief: 60 p. 100 of patients continuing to drink at the end of follow-up, did not suffer any longer. One year after pancreatic surgery, pain relief was more frequent, if alcohol abstinence had been obtained before surgery (p less than 0.01). Among the 53 patients followed up to 5 years after the start of pain: a) the cumulative actuarial probability of disappearance of pain was 17 p. 100 at 2 years, 52 p. 100 at 5 years, 62 p. 100 at 8 years after the start of pain. Alcohol abstinence and surgery were observed during the first five years of pain; b) the mean number of years of pain was lower among the patients who became abstinent early (less than 4 years after the beginning of pain) than among those who did not (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Alcoholism↗
PubMed1981

[Hepatology in 1981].

Explore the source record for details and available documents.

Chemical and Drug Induced Liver Injury↗
PubMed1981

[Hydatid cyst of the pancreas. One case (author's transl)].

This particular location is rare but should be more frequently detected with the help of ultrasonography, CT and serological tests. The surgical indications, which depend upon the effects of the cyst on pancreatic ducts and vessels, are discussed.

Adult↗
PubMed1981

[Follow-up of alcoholic patients in a hepatogastroenterology unit. Preliminary results (author's transl)].

Out of 126 alcoholic patients treated in a hepatogastroenrology unit, 55 were lost sight of after discharge, mainly because they lived far from the hospital, and 71 (56.3%) were followed up for a mean period of 10 months. Among the patients followed up, 11% showed clinical evidence, and 43.5% clinical and biochemical evidence (return to normal of mean corpuscular volume and gamma-glutamyl transpeptidase levels) of having stopped taking alcohol. Forty-five p. cent resumed drinking habits. Is was found that those patients who were married, had a professional activity, social contacts and no serious mental disorders were more likely to be weaned. There were more patients with cirrhosis of the liver among those who discontinued alcohol than among those who kept drinking. The authors underline that these subjects are best treated by a team comprising clinicians, psychiatrists, psychologists, social workers and members of associations of former alcoholics.

Alcoholism↗
PubMed1981

Upper digestive tract hemorrhage in cirrhotic patients. Contribution of multidimensional analysis to the study of variables related to the cause of the hemorrhage.

Sixteen clinical and biological variables were recorded in 116 episodes of upper digestive tract hemorrhage of known cause in cirrhotic patients. One-dimensional analysis reveals a significant correlation between six variables and the rupture of esophagogastric varices, whereas multiple linear regression and partial correlation analysis reduces the significant variables to two: a history of digestive hemorrhage and the nonalcoholic etiology of the cirrhosis. A value of the discriminant function exists for which the specificity and, consequently, the positive predictive value are equal to 100%, but with a sensitivity of 39%. These results mean that, in an explanatory approach, partial correlation analysis seems to constitute an indispensable complement to analysis of clinical and biological variables, since it reduces the chances of unwarranted explanatory interpretation. However, in a pragmatic approach, the recording of 16 variables does not permit a clear discrimination between ruptured varices and nonruptured varices; this suggests that either other factor(s) remain to be discovered or else that those related to ruptured varices and to acute ulcerations are the same.

Alcoholism↗
PubMed1981

[Modifications of disulfiram and its metabolites in blood in alcoholic hepatopathy (author's transl)].

In cirrhotic, steatosic and healthy subjects, the authors studied the metabolism of disulfiram (TETD) administrated orally (500 mg) 3 consecutive days. Carbon disulfide (CS2) and the whole TETD, diethyl dithiocarbamate (DDC) disulfides, were determined by a gas chromatographic method. The evolution of metabolites is similar in steatosic and healthy subjects. In cirrhotics the CS2, DDC and disulfides level increase within the 3 days. This phenomenon may be related with hepatic toxicity of TETD and with the persistence of disulfiram-alcohol reaction. The authors suggest to use low doses of disulfiram in cirrhotic.

Adult↗