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D Ladurner

Publications and source records attributed to D Ladurner.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Follicular thyroid cancer. A multivariate analysis].

The prognosis of malignant tumors is determined by a number of factors and their interaction. These factors may be assessed statistically by means of regression models for the hazard rates, which are assumed to be proportional. 89 follicular thyroid cancers from 1952 to 1975 were analysed according to clinical, macropathological and special histological criteria. Those variables which significantly influence the survival function were defined precisely and quantified by multivariate analysis. The age of the patients at the time of diagnosis (primary operation), sex, and local tumor extent (and therefore radical surgery) proved to be prognostically significant. Thus, the TNM system alone is sufficient neither for individual prognostic pronouncements nor for forming risk groups.

Adenocarcinoma↗
PubMed1984

[Papillary thyroid cancer--prognosis and prognostic factors].

90 papillary thyroid carcinomas (operated on between 1952 and 1977) were retrospectively analysed. The median follow-up is 5.29 years (range 0.08-29.42 years). After the primary operation only 68.9% of all patients may be classified as "tumor free". The lethality rate from thyroid cancer is 28.9%, the cumulative survival rates at 10 and 20 years are 50.92% and 32.06%, respectively. Thus survival is not significantly different from the one of our follicular carcinomas. The whole material was characterized thoroughly by clinical and morphological parameters. The simultaneous examination of the variables as to their prognostic relevance was performed by means of a log-logistic regression model for survival data. Age, extension of primary tumor, vascular invasion and presence of colloid determined prognosis. For the histopathological practice a differentiation between vascular and lymphatic invasion is demanded.

Adolescent↗
PubMed1983

[Prognosis of follicular thyroid cancer in the Tyrolean endemic goiter area].

89 follicular thyroid cancers (from 1952 to 1975) with detailed histology, complete clinical data and follow-up were analysed by several variables of which some prognostic importance could be expected. The observed survival times range from 0.08 to 27.75 years. Observed cumulative and expected survival rates were calculated and evaluated statistically. Evaluation of individual prognosis naturally demands a combination of histological, macropathological and clinical data: extent of primary tumor, capsular penetration and vascular infiltration, lymphnode involvement and distant metastases proved to be important parameters. The classification in intra-and extrathyroid carcinoma is to be preferred to the T-classification of the UICC, because it is simple and of great prognostic value.

Adenocarcinoma↗
PubMed1982

[Early diagnosis of thyroid cancer in endemic goitre area reflections and management based on the epidemiological situation in Tyrol (author's transl)].

Until recently the prognosis of thyroid cancer has been poor in this endemic goitre area due to the predominance of aggressive tumour types and belated diagnosis of the carcinoma. Iodine prophylaxis has changed this epidemiological profile: the mortality of goitre has generally decreased and there has been a relative increase in differentiated carcinomas. Preoperative diagnosis and operability have been favourably influenced by this new situation. Thus, whereas from 1960 to 1967 radical operation was impossible in 78.6% of thyroid cancers, between 1978 and 1981 only 12.4% of all cases had invasive tumours of distant metastases at the time of operation and 79.3% of all patients were staged as To-2N0Mo. An improvement in survival rate can be expected with early diagnosis of thyroid cancer. Nevertheless, individual prognostic statements can be made only after evaluation of these findings according to "prognostic systems", for in thyroid cancer--as in no other kind of carcinoma--prognosis is determined by a combination of the patient's age and sex, cell type and histological tumour pattern and TNM status.

Adenoma↗
PubMed1981

[Complications in thyroid surgery (author's transl)].

From 1975 to 1979 443 primary operations were performed in benign goiters. The total complication (intra- and immediately postoperatively) rate was 9.2%. Remarkable was the mortality rate of 0% and the rate of postoperative recurrent nerve palsy of 5.4%. The alterations of the surgical material by iodine prophylaxis and by extended thyroid diagnostics are shortly discussed. The topography of the recurrent nerve and its special items in endemic goiter area are described and the problems of intra-operative nerve preparation are commented.

Female↗
PubMed1980

[Endemic goitre before and after goitre prophylaxis (author's transl)].

Between 1952 and 1977 there has been a considerable change in the type of goitre operated on in the endemic area of the Austrian Tyrol. Iodine prophylaxis had proved significantly more effective in men: the consequences appear earlier and extend into the middle age groups. As a result, the type of surgical specimen is much more like that seen in non-endemic areas. The incidence of diffuse colloid goitre decreased, as that of adenomatous goitre increased. Among the adenomas, the number of the colloid-rich form has increased. Instead of diffuse or multinodular goitre one now frequently encounters the symptom-free, often uninodular, goitre. The total number of goitre operations has also decreased.

Austria↗
PubMed1980

[Atypical adenoma of the thyroid gland [author's transl)].

A total of 2204 nonmalignant goiters surgically removed during the years 1958, 1959, 1960 and 1966 were reexamined. Among them 181 adenomas were found, which were classified as 'atypical' by cytological respectively histological means. Those patients who had been primarily operated on at our hospital were questioned about the clinical course after the operation. Our results show a benign development of atypical thyroid adenomas, which means no recurrence of this type of adenoma nor metastasing in either of the cases during the observation period. The criteria of the WHO (Hedinger u. Sobin, 1974) for malignancy typing (with special emphasis on vascular invasion and caposular penetration and less attention to the histological structure and nuclear polymorphism) are thus verified. With exact histological exclusion of malignity, we believe, that in case of atypical adenoma, thyroidectomy is not necessary. Nevertheless a careful postoperative control of the patient is strictly indicated.

Adenoma↗
PubMed1977

[The intramural duodenal diverticulum, a topical variation of the intraluminal duodenal diverticulum (author's transl)].

The intramural duodenal diverticulum is a topical variation of the intraluminal duodenal diverticulum. It is manifested not before adult age by noncharacteristic upper abdominal symptoms. Diagnosis is made by radiologic examinations, the therapy is excision of the diverticulum. Structure and topography of the diverticulum are explained by its embryological development.

Adult↗
PubMed1975

[The significance of radioimmunological HPL determination in obstetrics (author's transl)].

The serum HPL level was studied in normal and high-risk pregnancies. 30 patients with premature labour showed significantly decreased levels. In 24 patients with monosymptomatic toxaemia, HPL patterns showed a statistically significant deviation from the normal standard curve; a highly significant decrease was observed in 23 cases of polysymptomatic gestoses. As opposed to the results of other authors, no significant difference from the normal distribution of HPL was found in cases of Rh sensitisation (13 patients) and diabetes mellitus (16 patients). A noteworthy results was seen in 19 cases of cervix insufficiency: after purse-string suturing of the cervix (original method of Shirodkar), the previously low plasma HPL level rapidly rose to normal levels. Because of the small number of cases without an adequate control group this phenomenon cannot be attributed with certainly, as yet, to the cerclage procedure.

Blood Group Incompatibility↗