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Biomedical subjects

D Laporte

Publications and source records attributed to D Laporte.

5 recordsLinked to original sources
PubMed2000

Introducing an evaluation of community based occupational therapy services: a client-centred practice.

The results of a study conducted in 1996 by the "Groupe de recherche en ergothérapie communautaire" (GREC), indicate that the quality of occupational therapy services in community settings is infrequently evaluated. A conceptual framework supporting such a process is presented in the context of client-centered services with a focus on continuous health care improvement. Both the research process leading to the design of an assessment tool, and its congruence with the beliefs and values of the profession, are explored. Finally, some issues relating to the implementation of a formal evaluation process are discussed.

Community Health Services↗
PubMed1987

Neutron scattering by calf lens cytoplasm. A comparison between two models of cataract.

Small angle neutron scattering (SANS) was used to compare two models of cataracts: the cold cataract induced in the lens nucleus cytoplasm by lowering the temperature and the opacification induced by calcium in the lens cortex cytoplasm. In both cases opacified cytoplasms display additional scattering at low angles as compared to their clear controls. An analysis of this additional scattering provides quantitative information concerning the size distribution, the number and contrast of the scatterers responsible for lens opacification. The scatterers of cold cataract and of calcium--induced opacification not only have, as shown elsewhere, a different composition but are also found to display completely different sizes (in the thousand A range for cold-cataract, in the hundred A range for calcium--induced opacification). These results illustrate the diversity of scatterer types which are able to cause comparable lens opacities.

Animals↗
PubMed1987

[Assesment of a satellite clinic : a five-year experience of a pedopsychiatric team in a disadvantaged area.].

Having worked closely for more than ten years with a team of child psychiatrists that defines itself as community-oriented, I attempt to describe the process by which this team became established in its designated territory. My aim is to provide an overview spanning the five years during which a "satellite clinic" established itself in a low-income district. I proceed by drawing a profile of the neighboring population and that which consults in particular, of agencies that refer and their motives for referral, as well as of our ways of responding to their requests. I also examine the collaboration with the various organizations in the district and what this entails with regard to hopes, doubts and conflict. Although being located within the designated territory had an overall positive impact on our work and our objective to prevent and detect anomalies, it has not necessarily been helpful in establishing better links with neighboring "support" organizations.

English Abstract↗
PubMed1986

Calf lens alpha-crystallin quaternary structure. A three-layer tetrahedral model.

Calf lens alpha-crystallins are polydisperse globular particles made of a large number of two types of subunits, A and B, both of molecular weight congruent to 20,000. alpha-Crystallin populations consisting on average of 40 subunits or more were subjected to various changes in pH, ionic strength, temperature and urea concentration. Modifications in quaternary structure induced by variation of these physicochemical parameters were followed by means of X-ray and quasi-elastic light-scattering and quantified in terms of weight average molecular weight (M), radius of gyration (Rg) and hydrodynamic radius (Rh). High-pressure liquid chromatography was used as a control of polydispersity. Increasing the pH, decreasing the ionic strength and incubating at temperatures from 20 degrees C to 45 degrees C all resulted in the formation of particles of decreasing M, Rg and Rh values. These effects are cumulative. All monomodal alpha-crystallin populations encountered in this study, which covers a wide range of sizes and molecular weights, may be accounted for by a three-layer model with partial filling up of the layers. Applying basic principles of symmetry and postulating specific contacts between protein subunits to construct this three-layer model leads to tetrahedral symmetry, with 12, 24 and 24 sites in the first, second and third layers, respectively. Variations in probabilities of site occupancy account for both the observed quaternary structure modifications and the intrinsic polydispersity of alpha-crystallins

Animals↗