Biomedical subjects
Publications and source records attributed to D Lazăr.
A compound obtained by the semisynthesis of theophylline and rutozid was analysed elementary and physicochemically. The performed analyses showed that it was 7-rutozidil-is-propanolen-theophylline.
A personal formulation of an ointment with antivaricose properties is presented. A methodology for the physicochemical and rheologic control, including all parameters required by the standards for ointments quality control, was designed. The analyses showed that the ointment is stable in time, has a thixotropic consistency and behaviour and does not require special preservation conditions.
Cicatrol ointment with the formula: argentic sulphamethoxydiasine 1 g, bentonite hydrogel 12.5% for 100 g is manufactured at the Microproduction Laboratory of the Faculty of Pharmacy of Iaşi. The one-year physicochemical determinations of the aspect, colour, homogeneity, pH, rheological behaviour and relative viscosity, content in argentic sulphamethoxydiasine as well as "in vitro" antimicrobial activity of Cicatrol showed a good stability and gel properties enabling an uniform and long-term contact with the wound. The clinical investigations carried out until now in patients with burns, varicose ulcers, trophic shank ulcers, superficial phlebitis with atonic ulcerations or wounds with multiple sites revealed its remarkable therapeutic value. As compared to other similar products, Cicatrol by its aseptic properties favours the scarring of any type of wound, a normal skin, without keloid scars being obtained, it also being well tolerated.
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