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Biomedical subjects

D Lees

Publications and source records attributed to D Lees.

27 records · Page 2Linked to original sources
PubMed1979

Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy.

Fourteen patients with a variety of neoplasms not responsive to standard forms of therapy underwent whole body hyperthermia for a maximum 4 h at 41.8 degrees C. This was a phase-I cancer trial designed to develop whole body hyperthermia as an adjuvant to systemic chemotherapy. Intravenous analgesia was used to sedate patients, obviating the need for general endotracheal anesthesia. Hyperthermia was induced by means of a high-flow water perfusion suit. Cardiovascular performance was evaluated using a flow-directed pulmonary artery catheter. Patients developed a twofold mean increase in cardiac index without evidence of cardiac damage by ECG or creatine phosphokinase (CPK) isoenzymes. An acute fall in serum magnesium and phosphate and an acute rise in arterial pH, serum CPK values, and granulocyte count occurred in all patients. There were no clotting abnormalities. Toxicity included fatigue, diarrhea, nausea, and transient elevations in liver enzymes. Four patients were febrile for 36 h after initial defervescence. Peripheral neuropathy developed in four. These results show that with carefully monitored conditions whole body hyperthermia is feasible.

Adolescent↗
PubMed1977

A case of hepatitis B with pleural effusion.

A case of viral hepatitis type B with associated large pleural effusion is repoted. Increased awareness of the association seems of clinical importance and may contribute to knowledge of auto-immune phenomena and the part they play in the inner-relationship of certain diseases.

Adult↗
PubMed1970

Health Services financing report: a review of appendices A-Q.

In May of this year after three years' work an advisory panel of the B.M.A., with Dr. I. M. Jones in the chair, produced a report on Health Services Financing.(1) A summary appeared in the Annual Report of Council(2) and a preliminary discussion on the report was held at the B.M.A.'s Annual Representative Meeting in July.(3) A full debate was deferred until the committees, divisions, and branches of the Association had had an opportunity to discuss the proposals. Nearly half of the book consists of appendices, commissioned from several economists, which cover the N.H.S. and the health services of 14 Western and some Eastern European countries. Below Professor Dennis Lees reviews these appendices, which formed a major source of information for the authors of the report and therefore have an important bearing on their conclusions.

Australia↗
PubMedDate not supplied

Surveillance of preservatives and their interactions in foodstuffs.

The organization of food surveillance in the UK is described, in particular as it has been applied to preservatives and their interaction products in foods. Applications of nitrates and nitrites as preservatives are discussed, together with the consequential exposure of consumers to these anions and their reaction products. Analytical methods for the determination of volatile and non-volatile N-nitroso compounds are referred to in relation to the results in food surveillance studies. Concentrations of Apparent Total N-nitroso Compounds (ATNC) averaged 2900 micrograms(N-NO)/kg in fried smoked bacon compared with 2400 micrograms/kg in fried unsmoked bacon; of this, known volatile and non-volatile N-nitroso compounds accounted for only 10-20%. ATNC were not detected in cheeses except those manufactured with added nitrate when ATNC levels up to 210 micrograms(N-NO)/kg were detected. Further studies are needed to determine the identity and toxicological properties of the non-volatile N-nitroso compounds.

Food↗