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Biomedical subjects

D Leighton

Publications and source records attributed to D Leighton.

8 recordsLinked to original sources
PubMed2001

Generating theory from the client's experience of same day laparoscopic sterilisation.

A grounded theory methodology was used to generate theory about the experiences of women undergoing laparoscopic sterilisation in a day surgery unit. Theories were developed on the role of client education in relieving anxiety, and the importance of privacy in all stages of client care. The grounded theory approach offered a client-centered model for day surgery planning.

Adaptation, Psychological↗
PubMed2000

Work-based musculoskeletal problems: initiatives to improve health.

Musculoskeletal disorders (MSD) are the leading cause of occupational ill-health in the UK and the level of suffering and costs associated with the current prevalence of MSD is of concern. In partnership with others, the Health and Safety Executive (HSE) is committed to tackling MSD. This will be achieved in part through the implementation of new wide-ranging, integrated policy initiatives and strategies, and through the HSE's core activities of publication of guidance, publicity campaigns and workplace visits by inspectors. A summary of these activities is presented, demonstrating that with new initiatives and partnerships, the HSE will continue to work towards greater awareness of occupational health issues and more effective management of health risks in the workplace.

Health Education↗
PubMed1985

Size and surface charge properties of myelin vesicles from normal and diseased (multiple sclerosis) brain.

Differences have been observed between myelin vesicles prepared from normal human central nervous system and from white matter of patients who died with multiple sclerosis (MS). The mean cross-sectional area of the vesicles was 5.69 +/- 0.17 micron 2 from normal myelin and 3.71 +/- 0.28 micron 2 for diseased myelin. Vesicle size was reduced to 4.08 +/- 0.21 micron 2 when normal myelin vesicles were prepared in the presence of 0.1 mM EDTA. The presence of Ca2+ during the preparation of the vesicles had no effect on the mean cross-sectional area. In the case of MS myelin vesicles, 0.1 mM EDTA had no effect on vesicle size, whereas the presence of Ca2+ increased the vesicle size from 3.71 +/- 0.28 to 5.40 +/- 0.31 micron 2. Electrokinetic analysis revealed that the electrophoretic mobility of normal myelin vesicles was -5.169 +/- 0.193 X 10(-8) compared with -6.093 +/- 0.202 X 10(-8) m2 s-1 V-1 for the MS myelin vesicles. The presence of 0.1 mM EDTA increased the electrophoretic mobility of the normal vesicles to -6.483 +/- 0.151 X 10(-8) m2 s-1 V-1 but did not significantly affect that of the MS vesicles. Addition of 0.1 mM Ca2+ decreased the electrophoretic mobility of both normal and MS vesicles to similar mobilities. From these data, the surface charge densities were calculated for both normal and MS myelin vesicles and found to be -2.93 and -5.39 mV m-1, respectively. The phase transition temperature determined by wide-angle x-ray diffraction studies was 63 degrees C for normal myelin vesicles and 43 degrees C for MS myelin vesicles.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain↗