PubMed Health⌕ Search

Biomedical subjects

D Lekim

Publications and source records attributed to D Lekim.

8 recordsLinked to original sources
PubMed1978

Phosphatidylcholine substrate specificity of lecithin:cholesterol acyltransferase.

Lecithin:cholesterol acyltransferase (LCAT) has been partially purified by the combined method of ultracentrifugation and dextranblue-2000 4 B affinity chromatography. The enzyme was incubated with liposomes consisting of phosphatidylcholine-cholesterol in a molar ratio of 10/1. Chemically synthesized phosphatidylcholine substrates with labeled fatty acids in 1-and 2-position were chosen to evaluate the degree of transesterification. It was found that the fatty acid in the 1-position of phosphatidylcholine significantly influences cholesteryl ester formation, both by its direct involvement in the LCAT reaction and its contribution to the physico-chemical properties of phosphatidylcholine.

Chemical Phenomena↗
PubMed1976

[Animal experimental studies on the pharmacokinetics of "essential" phospholipids (EPL)].

The pharmacokinetics of orally applied "essential" phospholipids (EPL) (i.e. polyenyl phosphatidyl choline) was investigated in conscious and in anesthetized rats with the aid of radioactively labelled dilinolyl phosphatidylcholines (3H and 14C.). Absorption, distribution and metabolism of EPL were studied using autoradiography and by measuring the distribution of the abosrbed radioactivity in lymph, blood and internal organs, and by determining excretion and expiration.

Administration, Oral↗
PubMedDate not supplied

Central action of sanumgerman administered orally in mice.

The behavioral and biochemical studies showed that daily oral administration of sanumgerman (340 mg/kg, i.e. 1/5 LD50) for 3 days exerted a depressive influence on the central nervous system of the mouse. The mechanism of this action could be related to an inhibition of catecholaminergic and of serotoninergic central system activities.

Administration, Oral↗
PubMedDate not supplied

Central action of sanumgerman in mice.

In the behavioral and biochemical investigations performed on Albino Swiss mice it was found that sanumgerman possessed inhibitory properties on the CNS. The mechanism of this action seems to be connected with depression of central catecholaminergic and a stimulation of central serotoninergic neurons.

Animals↗