[Dysplastic cyst of the diaphragm: limitations of diagnostic imaging].
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Biomedical subjects
D Leonello
Publications and source records attributed to D Leonello.
Detection of TSH-binding inhibiting immunoglobulins in patients with Graves' disease and non toxic goiter.
The test of TSH-binding inhibiting antibodies is proving to be very useful for diagnosis and prognosis of hyperthyroidism. The aim of this investigation was to detect, with radioreceptor assay system, the incidence of TSH-binding inhibiting immunoglobulins (TIBAb) in our people. Therefore were examined sera of 19 patients with Graves' hyperthyroidism (150 and 40, mean age 39.9 years, range 24-62) and 9 patients with non toxic goiter (70, 20 mean age 46.6 years, range 25-46) at the first assessment, during treatment along twelve months and after another four months at the end of drug management. 12/19 patients with Graves' syndrome were TIBAB positive (sensitivity 63%) before drug therapy. The prevalence of TIBAb in sera increased after therapy (14/19) but values at the end declined. Three patients (two with persistent high levels of TIBAb at the end of treatment) relapsed. TIBAb were negative in patients with non toxic goiter (and in all normal subjects).
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Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy.
The aim of this study was to investigate the time involved after hemithyroidectomy in reaching a new steady state in thyroid function and the relationship between thyroid hormones, basal TSH levels and TSH response to TRH. The investigations were performed on 35 patients 12-18 months after partial thyroidectomy in the first investigation and after 24-30 months in the second investigation. Tests included T4, T3, FT4, FT3 serum levels, basal serum TSH and TSH response to TRH. None of the patients received thyroid replacement and 38 healthy subjects of comparable age and sex were used as controls. We conclude that: i) the time involved in reaching a new steady state of thyroid function in hemithyroidectomized patients is variable and may take a long time; ii) TSH response to TRH returns to the normal range later than thyroid hormone and basal TSH levels.
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