Biomedical subjects

D Licci

Publications and source records attributed to D Licci.

4 recordsLinked to original sources

PubMed1985

Effects of chronic anticonvulsant monotherapy on endocrine system in prepubertal children with convulsive disorders. Preliminary data.

Effects of phenobarbital (PB), carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on endocrine functions were investigated in 7 clinically prepubertal children aged 5-10 8/12 years. The following meaning results were observed: normal PRL release, low basal T4 levels in PB-, CBZ-treated children and normal T4 basal level in the VPA-treated child; normal T3, rT3, TBG and TSH basal values and normal TSH release in all treated children, normal FSH release in PB-, CBZ- and VPA-treated females, high LH levels before and after LHRH injection in CBZ- and PB-treated females; normal levels in the VPA-treated one, normal basal FSH levels and increased releases in PB- and CBZ-treated males, high LH levels before and after LHRH injection in PB- and CBZ-treated males, normal basal and peak levels of GH.

Anticonvulsants↗

PubMed1985

Effects of anticonvulsant monotherapy in pregnancy on the newborn endocrine system. Preliminary data.

Pituitary-thyroid axis function and gonadotropin secretion were evaluated by a combined TRH and LHRH test in 4 newborn female infants appropriate for gestational age of mothers treated by AEDs throughout pregnancy. We found: high basal FSH levels with normal FSH reserve, normal LH-HCG levels both before and after LHRH stimulation, normal TSH and T4 levels both before and after TRH stimulation, high T3 basal values with a normal increase after TRH and low rT3 basal values. It is suggested an AED increased T4 deiodination towards T3 in the newborn liver without a marked impairment of the endocrine functions of the fetus.

Anticonvulsants↗

PubMed1984

Endocrine involvement in children with beta-thalassaemia major. Transverse and longitudinal studies. I. Pituitary-thyroidal axis function and its correlation with serum ferritin levels.

Thyroid function was investigated by a TRH test in 24 clinically prepubertal children, 3-15 years old with beta-thalassaemia major; in 7 of them the test was repeated once and in 2 twice at intervals of at least 12 months. Basal T4, T3, TBG and TSH levels and the TSH levels during a TRH test were determined and correlated with age and serum ferritin levels. Basal serum T4, T3 and TBG levels were lower and serum TSH levels were higher during the test and in the basal state in thalassaemia major children than in control children. These results show a compensated sub-clinical primary hypothyroidism. The transversal study did not show any significant correlation between the hormonal parameters studied and chronological age or serum ferritin levels. In contrast, the longitudinal study showed a significant correlation between pituitary-thyroidal axis function and siderosis (positive correlations between the variations of TSH levels as delta, peak, 30 and 45 min values and the variations of serum ferritin levels). The thyroid impairment seems not to be correlated with serum ferritin levels in the transversal study because of the presence of an individual different sensitivity of the gland to the iron overload. The ferritin dependence of this impairment is shown only by longitudinal studies where individual differences in sensitivity of the gland are absent.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1981

Endocrine function in four anencephalic infants.

Endocrine studies of 4 anencephalic infants were carried out. No hypothalamic or hypophyseal structures could be found in any of them macroscopically, but we cannot say that there were no functioning pituitary cells which might have been seen microscopically. A combined LH-RH and TRH test was performed in the 6th h of life, followed by an intravenous glucose tolerance test 1 h later. Our data suggest that: (1) adenohypophyseal tissue, present in anencephaly even in the absence of a hypothalamus, is able to synthesize PRL and TSH autonomously and, under specific stimulation, PRL, TSH, and ACTH can be released while FSH and LH-HCG are not, hGH secretion is doubtful; (2) the circulating hGH and TSH surges that normally occur after delivery are hypothalamus-dependent and do not occur in anencephalics; (3) the thyroid and adrenals are able to synthesize hormones when specifically stimulated, even in the absence of the hypothalamus, and (4) beta-pancreatic function is not markedly impaired in anencephaly.

Anencephaly↗