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Biomedical subjects

D Lobel

Publications and source records attributed to D Lobel.

16 recordsLinked to original sources
PubMed1987

Morphological response of injured adult rabbit optic nerve to implants containing media conditioned by growing optic nerves.

Adult rabbit retina can express regeneration-associated characteristics after optic nerve injury, provided it is supplied with appropriate diffusible substances originating from media conditioned by regenerating fish optic nerves or by optic nerves of a newborn rabbit [Hadani et al., Proc. Natl. Acad. Sci. U.S.A., 81 (1984) 7965; Schwartz et al., Science, 228 (1985) 600]. This was shown by applying the active substances to the injured axons in the form of 'wrap-around' implants, consisting of collagen-coated silicone tubes which had been soaked in the conditioned media (CM). The regeneration-associated response was manifested biochemically and by sprouting of nerve fibers in culture. The present work provides morphological evidence that the implantation prolongs survival of ganglion cells and optic nerve fibers and induces new growth. Light microscopic analysis (using horseradish peroxidase (HRP) for labeling the fibers) revealed, 1 week following optic nerve injury, labeled fibers and ganglion cells in both the implanted and control (injured only or injured and implanted with collagen-coated silicone tubes free of CM) nerves. However, from the second week after the injury, distinct differences in the appearance of viable ganglion cells and labeled fibers, were seen between experimental and control preparations. In sections taken through the optic nerve, at the region distal to the site of injury, HRP-labeled fibers were seen in the experimental nerves 1 week, 2 weeks and to a significantly lesser extent 1 month after injury.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1980

Instant photography with the Polaroid SX-70 Alpha I camera mounted on a slit lamp.

A readily adjustable, quick-mounting attachment frame allows use of an unmodified Polaroid SX-70 Alpha I camera with several available ophthalmic slit lamps. Initial results with this arrangement have proved to be easily obtainable and of good quality. Several important uses for instant color photographs obtained with this sysetm are suggested here.

Eye Diseases↗
PubMed1979

Hand-held slit lamp with a lid opener.

During ocular examinations, it often is necessary for the doctor to both inspect and treat the eye simultaneously. An instrument has been developed which makes this process considerably simpler.

Humans↗
PubMed1978

A new magnetic technique for the treatment of giant retinal tears.

Using surgical techniques similar to those for closed vitreous surgery, we introduced a small magnetic sphere into the intraocular cavity of experimental animals. The sphere was subsequently maneuvered gently over the retina to unfold and reposition it with a small external permanent magnet probe. We used 68 enucleated canine eyes; eight eyes were operated in vivo and then examined microscopically. Retinal damage was caused by friction and excessive pressure when we used external magnets that were too strong or spheres that were too large. When small intraocular magnetic spheres coated with silicone or teflon or encased in a hollow oversize epoxy sphere were used the damage to the retina was minimal, or absent. We suggest using this same technique to treat retinal tumors through the introduction of radioactive material or antitumoral drugs. The intraocular magnetic sphere of this type would be left inside the eye in contact with the lesion for an extended period (seven days to three months) by suturing a small magnet to the sclera over the lesion.

Animals↗
PubMedDate not supplied

Lid suture myopia in developing chicks: optical and structural considerations.

In a group of chickens studied after lid suture in the first month post hatching an unusually high myopia was found (n = 8 eyes; average: -21.87 Diopters). The non-operated eyes of these chicks had the same optical properties (n = 4; +0.93 Diopters) as the eyes of the normal control chicks (n = 12; +0.81 Diopters). Although enlargement of the whole eye occurred, the main determinant was an axial elongation (operated eyes, 18.0 mm; nonoperated, 13.7 mm; normal controls, 14.7 mm). The axial change involves an enlargement of the posterior as well as the anterior segments of the eye. Despite several structural characteristics specific to chicks, their eyes can serve as a model for myopia research.

Animals↗