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D Loeb

Publications and source records attributed to D Loeb.

8 recordsLinked to original sources
PubMed1995

Physical and genetic mapping of the CMT4A locus and exclusion of PMP-2 as the defect in CMT4A.

We have previously localized one form of the autosomal recessive Charcot-Marie-Tooth disease type 4 (CMT4A) to a 5-cM region of chromosome 8q13-q21. We now report the formation of a 7-Mb YAC contig spanning the region. This contig was used to map nine additional microsatellites and six STSs to this region, and subsequent haplotype analysis has narrowed the CMT4A flanking interval to less than 1 cM. In addition, using SSCP and our physical map, we have demonstrated that the myelin protein PMP-2, mapped by FISH to this region, is not the defect in CMT4A.

Adaptor Proteins, Signal Transducing↗
PubMed1986

Puerperal Pasteurella multocida septicemia.

A case of Pasteurella multocida infection in a puerperal healthy young women is reported. The agent was isolated from vaginal discharge and blood cultures of the patient, and also from pets and poultry with which the patient was in contact. Although Pasteurella multocida septicemia is rare, awareness of this infection and adequate intensive antibiotic therapy may improve its prognosis.

Adult↗
PubMed1984

Two forms of ornithine decarboxylase activity in mouse kidney.

Renal ornithine decarboxylase (ODC) activity was evaluated in normal female, male, testosterone-treated female and androgen-insensitive Tfm/Y mice for its heat sensitivity and in vivo half-life. ODC activity in normal female kidney consisted of 2 forms which differed in their heat sensitivity at 46 degrees C. Androgens, either endogenous in normal males or administered exogenously to females, induced primarily the heat-sensitive form. Results from mixing experiments indicated that the heat-sensitive form represented a change in the property of the ODC activity rather than a change in cytoplasmic factors. The in vivo half-life of ODC activity was increased slightly in males and short-term androgen-treated females over normal females and was markedly increased by prolonged androgen treatment. In vivo, the androgen-induced, heat-sensitive form decayed faster than did the heat-resistant form. We conclude that androgens have specific effects on both the amount as well as the biochemical properties of ODC activity in mouse kidney.

Animals↗