Biomedical subjects
D Low
Publications and source records attributed to D Low.
A computerized biochemical profile for detection of alcoholism.
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An empirical analysis: variables affecting physicians' hospice care adoption.
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Alcoholism assessment on an orthopaedic surgery service.
We reviewed the initial history, obtained by the orthopaedic house staff, of each of eighty-seven patients who were consecutively admitted to an acute orthopaedic-surgery service. A diagnosis of alcoholism was made by the house staff in only one of every ten patients who had been identified as having symptoms of alcohol addiction in a previous study. Alcohol abuse was identified in only five of every ten such patients. Of the orthopaedic patients in this sample who had been shown to be abusing alcohol, 37 per cent were neither suspected nor diagnosed as abusers by the orthopaedic house staff. We recommend the use of a brief screening interview (CAGE) to increase diagnostic effectiveness in this area, and discuss the clinical usefulness of an early diagnosis of alcoholism among orthopaedic surgical patients.
Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats.
An artificial pancreas consisting of beta cells cultured on synthetic semipermeable hollow fibers was tested in rats with alloxan-induced diabetes. When implanted ex vivo as arteriovenous shunts in the circulatory system these devices lowered concentrations of plasma glucose from 533 to between 110 and 130 milligrams per 100 milliliters, increased concentrations of plasma insulin, and restored intravenous glucose tolerance tests essentially to normal.
Antibacterial action of the essential oils of some Australian Myrtaceae with special references to the activity of chromatographic fractions of oil of Eucalyptus citriodora.
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Interaction between pap-encoded pilin and adhesin gene products of uropathogenic Escherichia coli.
Uropathogenic Escherichia coli are major causative agents of cystitis and pyelonephritis. Most E. coli pyelonephritis isolates express pili encoded by the pyelonephritis-associated pili (pap) gene cluster. The pap DNA sequence encodes pilin monomers that are assembled into pili fibers; pap also encodes adhesins that recent results suggest might be located at the tips of the pilus fibers. The study presented here is a status report of work that has two major goals: to determine (1) if any Pap proteins associate with pili and (2) if Pap proteins not required for pili assembly affect levels of pili-cell surface expression. To address the first aim, antisera to pili were used to precipitate pili from detergent extracts containing 35S-labeled Pap proteins. The results suggested that a protein of 16-kilodaltons apparent molecular mass associated with pili. Other interpretations of the data are discussed. The second aim was addressed by constructing E. coli strains that contained different pap regions. With the use of electron microscopy and a pili ELISA, it was found that E. coli containing a 6.5-kilobase-pair region of pap expressed low levels of pili, but no P-adhesin was detected. Transformation of this E. coli strain with a plasmid containing an additional 3.5-kilobase-pair pap DNA sequence resulted in an eightfold increase in pili expression as well as expression of P adhesin. These results indicated that pili expression was affected by Pap proteins not required for pili assembly.