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Biomedical subjects

D Lowe

Publications and source records attributed to D Lowe.

At least 199 records · Page 11Linked to original sources
PubMed1981

Cervical carcinoma in Malawi: a histopathologic study of 260 cases.

Cervical carcinoma is the commonest malignancy seen in histopathologic material from Malawi. Between 1975 and 1978, 460 cases were diagnosed, of which 431 were invasive squamous carcinomas. These were reviewed for degree of differentiation and placed into three histologic types. Large cell non-keratinizing carcinoma was the commonest type, and presented at an earlier clinical stage than either large cell keratinizing or small cell non-keratinizing tumors. Of all tumors, 2.8% showed a massive eosinophil infiltrate which was not related to schistosome infection. The clinicopathologic features of cervical carcinoma in Malawi appear to be similar to those found in the United States and Europe.

Adult↗
PubMed1981

DNA polymerase of a basidiomycete fungus, Coprinus cinereus.

DNA polymerase activity was studied in Coprinus cinereus, a basidiomycete fungus. Only one from of the enzyme could be demonstrated, whether by affinity or ion-exchange chromatography; this enzyme had a molecular weight of 185000 on Sephadex G-200, and was inhibited by mercaptoethanol. Coprinus, a representative of the most advanced type of the filamentous fungi, resembles other eukaryotic micro-organisms in its lack of a mammalian beta-type DNA polymerase. The properties of the polymerase are compared with those of two other fungi, and found to resemble most closely the yeast polymerase A in Mg2+ requirements and template preference.

Agaricales↗
PubMed1981

Tumour-associated eosinophilia: a review.

In a recent study of cervical carcinoma, 13 cases with a marked eosinophil infiltrate around the tumour were found. The histological appearance of the tumours was distinctive and suggested a specific response, similar to the lymphocyte infiltration in medullary carcinoma of the breast and seminoma. A review of published reports shows that tumour-associated tissue eosinophilia (TATE) and tumour-associated blood eosinophilia (TABE) may be seen in tumours of different histological types from different anatomical sites, and may occur together or separately. Tumours with TATE alone appear to have a better prognosis that those without, while TABE is associated with tumor spread and a poor prognosis.

Animals↗
PubMed1981

The use of minor tranquilizers with jail inmates.

The decision of whether or not to prescribe minor tranquilizers becomes an apparent dilemma for mental health professionals working in jails. By dispensing anxiety-reducing drugs, they may help the inmate cope with existing hardship conditions, but they may also contribute to drug dependency. A survey of California county jail systems revealed a general distrust of minor tranquilizers as a therapeutic modality. The authors conducted a medication-linked group therapy program in one county jail to provide an alternative to the usual policies governing use of tranquilizers.

Anti-Anxiety Agents↗
PubMed1981

The isolation of Phoma eupyrena from a human lesion.

A strain of the soil-borne fungus Phoma eupyrena was isolated from the skin of an 18-month-old boy who had a crusting, erythematous, perioral eruption of one month's duration. Treatment with clotrimazole, 15% zinc oxide paste, and dimethicone resulted in eradication of the fungus and in complete healing of the lesions in eight weeks.

Clotrimazole↗
PubMed1980

Erythema nodosum migrans in a young woman.

A case of erythema nodosum migrans in a 16-year-old girl is reported. We believe this to be the youngest patient described to date. The patient responded promptly to therapy with potassium iodide. The causes, pathogenesis, and treatment of the condition are discussed.

Adolescent↗
PubMed1976

A large intrathoracic parathyroid adenoma.

A case is described in which an unusually large parathyroid adenoma was visible on the plain chest radiograph taken during the investigation of hypercalcaemia. This was diagnosed preoperatively and a scheme is suggested whereby such a disgnosis can now readily be made. The differential diagnosis is discussed ant the literature is reviewed.

Adenoma↗
PubMed1976

Benign and malignant teratomas in children: analysis of 85 patients.

Teratomas were observed in 85 infants and children. Fifty-eight (68%) were girls and 27 (32%) boys. Site of origin was sacrococcygeal in 55 patients (64.8%), mediastinal in ten (11.7%), gonadal in ten (11.7%), presacral in four (4.8%), retroperitoneal in three (3.5%), and cervical in three (3.5%). Sixty-seven (78.8%) teratomas were benign and 18 (21.1%) malignant. Malignant tumors were noted in 11 of 55 sacrococcygeal (20%), two of ten mediastinal (20%), three of eight ovarian (37.5%), and both testicular lesions. Cervical, retroperitoneal, and presacral tumors were benign. Age at diagnosis (greater than 1 month), presence of symptoms (urinary and colonic obstruction), and serum positive for alpha fetoprotein were indicators of malignancy in sacrococcygeal cases. Age was not a factor for teratomas at other sites. Tumor size, presence of calcification, and gross appearance (cystic or solid) did not relate to the tumor's benign or malignant nature. Three of four presacral tumors were associated with anorectal anomalies. Operative resection is the treatment of choice. Four deaths were related to operative hemorrhage. Four of five survivors with malignant teratoma received radiation and chemotherapy. A more aggressive role for combined adjunctive measures is suggested in cases of malignancy.

Abdominal Neoplasms↗
PubMed1975

The effect of "ouabain" on the ultrastructure of cerebral arterioles and surrounding tissue, studied by a cannulation of a cerebral artery.

A technique for cannulation of a parietal branch of the middle cerebral artery is described by which high but local concentrations of substances can be achieved in cortical vessels. Using this technique it was shown that ouabain, a specific inhibitor of the Na+-K+-ATPase enzyme system, can produce alterations in the blood brain barrier (BBB) permeability as seen by the passage of Evans Blue into cortical tissue. Electron microscopy revealed changes in the endothelium of cerebral arterioles ranging from an increase in the number of vesicles and vacuoles to complete breakdown of cytoplasm and membranes. Swelling of the peri-arteriolar end feet of protoplasmic astroglia and of dendrites was characteristic of tissue surrounding affected arterioles. Swollen fibrous astrocytes, oligodendrocytes and microglia were not seen even in areas of vasogenic edema. These results are discussed in terms of current ideas of the BBB and astroglial function.

Animals↗
PubMed1973

Preferential synthesis of a membrane-associated protein by free polyribosomes.

Isolated free polyribosomes from rat liver appear to synthesize NADPH-cytochome c reductase in vitro four times as efficiently as do membrane-bound polyribosomes. The observed synthesis by the latter could result from contamination with free polyribosomes, but an alternative explanation is also suggested.

Amino Acids↗
PubMed1971

Thyroid suppressibility: follow-up for two years after antithyroid treatment.

In hyperthyroidism suppression and non-suppression of early radioiodine neck uptake by exogenous thyroid hormone after a course of antithyroid drugs does not indicate clearly those patients who will eventually relapse or have a remission. Sixty-four hyperthyroid patients have been followed up for two years after an 18 to 24 months' course of carbimazole. Twenty-eight patients had suppressed at the end of the carbimazole course and 20 of these remained in remission for two years, and 36 were non-suppressed and 21 of these relapsed.Patients with the highest neck uptakes relapsed soonest after stopping treatment. Pronounced rebound occurred in neck uptakes at one month after stopping treatment, both in patients who relapsed and in those who remained in remission. By one year after stopping treatment those who remained in remission had shown a further fall in early neck uptake. In two patients who relapsed after exposure to stressful events no change in 20-minute radioiodine neck uptakes was found in relation to the supposed stress.

Antithyroid Agents↗