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Biomedical subjects

D M Aviado

Publications and source records attributed to D M Aviado.

At least 73 records · Page 4Linked to original sources
PubMed1970

Pharmacological significance of biogenic amines in the lungs: histamine.

1. Eight animal species were investigated for the histamine content of the lung and can be divided into two groups: the low-level group, ranging from 2 to 7 mug/g, consisting of the mouse, rat, guinea-pig and rabbit; and the high-level group, ranging from 12 to 35 mug/g, consisting of the cat, dog, goat and human. In two species of the high-level group (cat and dog) the amount of histamine that elicited an increase in pulmonary resistance was one-fifth to one-tenth of the dose that elicited an increase in species of the low-level group (rat and rabbit). There is an inverse relationship between the content of histamine and the dose of histamine that produces a 25% increase in pulmonary resistance.2. Anaphylaxis increases the histamine content of the lung of the rabbit but not of the lung of the guinea-pig. In both species, anaphylaxis is accompanied by an elevation of the concentration of 5-hydroxytryptamine in the lung, indicating the trapping of platelets in the lung.3. The development of severe parasitaemia in the mouse inoculated with Plasmodium berghei is accompanied by an elevation of the histamine content of the lung. This increase appears to be part of the response of the lung to parasitaemia.

Albumins↗
PubMed1970

Pharmacological significance of biogenic amines in the lungs: noradrenaline and dopamine.

1. The noradrenaline concentration in the lung was less than 0.5 mug/g in eight animal species.2. In the cat, dog, rabbit and goat, tyramine produced a fall in pulmonary resistance, which was reduced by the administration of either reserpine or cocaine. Although an infusion of noradrenaline increased the content of this amine in the lung of the cat, previously depleted by reserpine, the bronchodilator property of tyramine was not restored. The infusion of isoprenaline did not restore the response to tyramine. The role of either catecholamine in mediating the bronchomotor response to tyramine could not be ascertained.3. The concentration of dopamine was as high as 6.4 mug/g in the goat lung and less than 0.5 mug/g in the lungs of the cat, rabbit, dog, rat, mouse, guinea-pig and man. Dopamine, injected intravenously into the cat, dog, rabbit and goat, produced a slight rise in pulmonary resistance. This increase was blocked by tolazoline, indicating that the response was mediated by alpha-adrenoceptors in the bronchial passages. No procedure has been observed to influence the dopamine content of the lung. The release of dopamine cannot, however, be excluded until the blood in the bronchial veins has been analysed.

Anilides↗