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Biomedical subjects

D M Coles

Publications and source records attributed to D M Coles.

7 recordsLinked to original sources
PubMed1983

Acute amphetamine cardiomyopathy in a drug addict.

A case of acute left ventricular failure following an intravenous dose of amphetamine is described. The diagnosis was made by right heart catheterization. This is the first description of acute amphetamine cardiomyopathy in the medical literature.

Acute Disease↗
PubMed1983

Torsade de pointes and asystole in a child with complete heart block and prolonged QT interval.

Three-year-old girl with eight month history of convulsive syncope due to complete heart block, prolonged QT interval and paroxysms of ventricular tachycardia is described. An episode of torsade de pointes tachycardia followed by asystole was documented. The symptoms and electrocardiographic abnormalities were controlled by pacemaker therapy. The subset of "congenital heart block" patients with prolonged QT interval is at high risk of sudden death and should be regarded as a previously unrecognized form of Romano-Ward syndrome.

Arrhythmias, Cardiac↗
PubMed1981

Absorption of quinidine and dihydroquinidine in humans.

Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. In all subjects, dihydroquinidine was absorbed to a lesser extent than quinidine. On the basis of comparative AUC pu to 6 h after administration, dihydroquinidine was 73% as available as quinidine. Rates of elimination of the compounds were similar. No correlation could be found between saliva and plasma levels for either compound. Limits for content of dihydroquinidine in commercial quinidine preparations seem essential to ensure adequate bioavailability.

Adult↗
PubMed1975

Australian pacemakers: a follow-up survey.

The Royal Prince Alfred Hospital experience with Australian-made pacemakers shows that the Telectronics P7 fixed-rate pacemaker has a 90% survival rate at two years. Such a figure compares favourably with those of its predecessor and other makes of pacemaker. Survival of the P6 ventricular synchronized units is slightly less than that of the P7.

Aged↗
PubMed1975

Resolution of an iatrogenic coronary artery thromboembolus.

A patient with an iatrogenic coronary thromboemboulus, sustained during selective left coronary catheterization is presented. The embolus was identified by angiography and its complete resolution was documented in the same manner three months later. Despite chest pain and elevation of the cardiac enzymes, the electrocardiogram showed only nonspecific changes and the absence of macroscopically identifiable infarction was demonstrated at thoracotomy. Thromboembolization may be a more common cause of complication with the Judkins technique than generally realized but may be compatible with complete recovery and be avoided by special catheterization practices.

Cardiac Catheterization↗