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Biomedical subjects

D M Holt

Publications and source records attributed to D M Holt.

6 recordsLinked to original sources

Recommendations, usage and efficacy of immunizations for the elderly.

Significant levels of older-adult mortality and morbidity are associated with vaccine-preventable diseases, specifically influenza and pneumococcal disease. Even though current guidelines for this age group recommend a single vaccination against pneumococcal pneumonia, an annual influenza vaccination and a combined tetanus-diphtheria toxoid booster every 10 years after completion of a primary series, immunization levels remain extremely low. This article presents information regarding usage, efficacy and cost-effectiveness of these vaccines. Physician non-compliance and misinformation, negative patient attitudes and a shortage of effective programs for vaccine delivery account for vaccine underutilization. Recommendations from health care providers significantly affect whether a person will be immunized. Increased vaccine usage was noted in clinic-based programs that initiated organizational or administrative interventions, such as patient and physician reminders, physician-performance feedback, medical-record checklists and the use of non-physician health care staff to monitor patient vaccination status and to dispense vaccines. Providing organized education and vaccination programs in institutional and public settings may also help target the older-adult population. The future success of adult immunization will depend not only on increased professional and public awareness but also on the development of new approaches to vaccine delivery.

Aged

Bacterial degradation of lignified wood cell walls in anaerobic aquatic habitats.

Test blocks of beech (Fagus sylvatica) and Scots pine (Pinus sylvestris) were buried in fresh, brackish, and seawater anaerobic muds for periods ranging between 1 and 18 months. At appropriate time intervals the test blocks were recovered and examined for changes in weight and for bacterial attack of lignified wood cell walls. Only small weight losses occurred. Scanning electron microscopy studies revealed that there was extensive superficial bacterial erosion of beech wood cell walls. The decay patterns are illustrated by micrographs and discussed in relation to other types of bacterial attack.

Bacteria, Anaerobic