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Biomedical subjects

D M Hunter

Publications and source records attributed to D M Hunter.

12 recordsLinked to original sources
PubMed1992

Effects of isopropyl alcohol, ethanol, and polyethylene glycol/industrial methylated spirits in the treatment of acute phenol burns.

STUDY OBJECTIVE: To compare the effects of water rinse with those of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or ethanol on cutaneous phenol burns. DESIGN: Controlled trial with all animals receiving all treatments applied to different cutaneous phenol burn sites. TYPE OF PARTICIPANTS: Swine weighing 9 to 18 kg. INTERVENTIONS: In phase 1, each burn site was treated with water rinse for zero, one, or five minutes combined with either isopropyl alcohol, polyethylene glycol with industrial methylated spirits, ethanol, or no other treatment. Biopsies of treatment sites were done at 30 minutes and at 48 hours. In phase 2, a pilot study, the effect of isopropyl alcohol, polyethylene glycol with industrial methylated spirits, or water treatment on serum phenol levels was noted in animals with 5%, 10%, and 15% body surface area burns. MEASUREMENTS AND MAIN RESULTS: In phase 1, on histological examination of biopsy specimens, significant differences in tissue damage occurred among the groups (P < .05). Isopropyl alcohol and polyethylene glycol with industrial methylated spirits were the most efficacious treatments; the duration of water rinse had no significant effect. In phase 2, the systemic absorption of phenol may be greater with water treatment than with isopropyl alcohol treatment. CONCLUSION: Isopropyl alcohol and polyethylene glycol with industrial methylated spirits are equally effective in the amelioration of phenol burns of less than 5% total surface area. The wider availability of isopropyl alcohol makes it potentially the most useful treatment for these small burns. Further studies of its risks are needed.

1-Propanol↗
PubMed1990

Production and use of murine monoclonal antibodies reactive with bovine IgM isotype and IgG subisotypes (IgG1, IgG2a and IgG2b) in assessing immunoglobulin levels in serum of cattle.

Utilizing in-vitro and in-vivo immunizations, murine monoclonal antibodies (Mab's) that are specific for bovine immunoglobulin (IG)--IgM isotype and IgG subisotypes (IgG1, IgG2a and IgG2b)--have been produced. These Mab's were used to estimate the quantities of these bovine Ig isotype and IgG subisotypes in the sera of 56 cows and 24 bulls. The cows were all approximately 18 months of age and the bulls ranged from 12 to 18 months in age. The cows and bull were all apparently healthy and unimmunized. The cows were not pregnant and were nulliparous. Some differences were observed between the serum levels of IgM (higher in cows) and IgG1 (higher in bulls). No ready explanation can be offered for these observed differences.

Animals↗
PubMed1989

Optic nerve pseudomeningioma secondary to localized amyloidosis.

A 55-year-old woman presented with a mass of the optic nerve sheath suggestive of a meningioma. On excision, this proved to be amyloid. No systemic involvement could be found. Although amyloid may arise as a solitary lesion of the orbit or extraocular muscle, this "pseudomeningiomatous" pattern has not been previously noted. A magnetic resonance scan was helpful because the amyloid imaged at a density similar to vitreous and cerebral white matter, unlike meningiomas, which appear more like bone. The diagnosis of localized amyloidosis, however, still remains dependent on histopathology and cannot be made on a clinical basis.

Amyloidosis↗
PubMed1977

Fluorescein angiography and light microscopy studies of retinas irradiated by oxygen nuclei.

Fluorescein angiography and light microscopy techniques were utilized in the rhesus monkey to evaluate retinal damage following oxygen ion irradiation. Particle flux ranged from 1.3 x 10(7) particles/cm2 to 1.5 x 10(8) particles/cm2. Earliest evidence of damage was detected with fluorescein angiograms 24 h after exposures to 7.7 x 10(7) particles/cm2. No evidence of the hypothesized microlesion was found by either technique.

Angiography↗
PubMed1977

Heavy-ion-induced cataractogenesis.

Cataract formation following heavy ion exposure (O+8) was noted in three rhesus monkeys secondary to a study of retinal effects. The pathogenesis of these lens changes follows many, but not all, of the characteristics for "radiation cataracts." The ring-shaped opacity was not noted to occur. Posterior capsular changes were noted initially and followed through the formation of a mature cataract.

Animals↗
PubMedDate not supplied

X-ray imaging using amorphous selenium: a photoinduced discharge readout method for digital mammography.

A new digital image readout method for electrostatic charge images on photoconductive plates is described. The method can be used to read out images on selenium plates similar to those used in xeromammography. The readout method, called the air-gap photoinduced discharge method (PID), discharges the latent image pixel by pixel and measures the charge. The PID readout method, like electrometer methods, is linear. However, the PID method permits much better resolution than scanning electrometers while maintaining quantum limited performance at high radiation exposure levels. Thus the air-gap PID method appears to be uniquely superior for high-resolution digital imaging tasks such as mammography.

Female↗