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D M Jaffe

Publications and source records attributed to D M Jaffe.

41 records · Page 3Linked to original sources

Developing a clinical algorithm for early management of cervical spine injury in child trauma victims.

To define a subset of injured children for whom emergency cervical spine radiography may be unnecessary, we performed a retrospective chart and radiologic review. Two entry methods were used: All injured children, from birth through 16 years, who had received cervical spine radiographs at The Children's Memorial Hospital from September 1983, to September 1984, were included. All patients from birth to 16 years with proven or suspected cases of cervical spine injury who had received cervical spine radiographs and who had been treated at either the Children's Memorial Hospital or the Northwestern University Spine Trauma Unit during period 1974 to 1984 also were included. Each child's chart was reviewed, and 84 clinical variables were recorded. All radiographs were reviewed by a pediatric neuroradiologist. Of 206 children studied, 59 had cervical spine injuries. A clinical algorithm was derived using the following eight variables: neck pain; neck tenderness; limitation of neck mobility; history of trauma to the neck; and abnormalities of reflexes, strength, sensation, or mental status. The following decision rule was selected: Positive findings in any of these eight variables mandates cervical spine radiography. This algorithm correctly identified 58 of 59 children with cervical spine injury, yielding a sensitivity of 98% and specificity of 54%. Cervical spine radiographs could have been avoided in 79 children (38% of the entire sample). This algorithm performed better than did models derived from logistic regression analysis of the same data. Validation trials are required prior to the implementation of this or other clinical decision algorithms in practice.

Accidents↗

Evaluation of the "tilt test" in children.

The "tilt test" (assessment of orthostatic pulse and blood pressure) is a non-invasive screening test for acute intravascular volume loss with well-accepted utility in the emergency evaluation of adults. Its value in children has been questioned because of reports of high false-positive rates. We report a prospective study to compare "tilt test" results between children with and without clinical volume depletion in a pediatric emergency setting. Children 4 to 15 years old seeking care at an urban pediatric emergency department were eligible. Children meeting the following criteria were classified as dehydrated: an acute history of vomiting or diarrhea and a volume depletion score greater than or equal to 4. The control sample was selected from children with minor complaints, and a volume depletion score less than 4. Blood pressure and heart rate were recorded at one-minute intervals by an automatic noninvasive blood pressure monitor for three minutes in the supine position. Subsequently, measurements were taken for two minutes in the standing position with the arm supported at heart level. Sixteen dehydrated and 21 normal children were enrolled; the groups were comparable in mean age, weight, sex, and oral temperature, but differed significantly in racial background. The mean orthostatic rise in heart rate was 29.1 beats per minute (+/- 10.7) in the clinically dehydrated group and 13.1 beats per minute (+/- 8.5) in the control group (P less than .001). There was no significant difference between the two groups with respect to the small decrease in systolic blood pressure (0.38 and 0.46 mm Hg).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Disuse atrophy of skeletal muscle. A morphometric study using image analysis.

A morphometric study of disuse atrophy was done on the rat anterior tibilalis muscle over a 13-day period after immobilization of the hind leg by pinning the knee and ankle joints. Cross-sectional areas of individual muscle fibers were measured using image analysis, a new and precise technique. Three types of muscle fibers, light, medium and dark, were defined using a modified myosin-ATPase reaction on cryostat-cut sections. Each of the 3 fiber types was found to show a degree and time course of atrophy unique to itself. At the 0.01 confidence level, the dark fibers (with strongest ATPase reaction) did not shrink significantly. Both the light (ATPase negative) and medium fiber did show significant atrophy at that level; the light shrinking more than the medium. Simple visualization of the light microscopic images was often found to be misleading. Thus, the need was documented for a precise technique for analysis of fiber size distribution.

Animals↗