URINARY HISTAMINE EXCRETION IN THE GASTRECTOMISED RAT.
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Biomedical subjects
Publications and source records attributed to D M SHEPHERD.
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A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than alpha-methyldopa [beta-(3,4-dihydroxyphenyl)-alpha-methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.
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