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D M Storey

Publications and source records attributed to D M Storey.

At least 37 records · Page 2Linked to original sources
PubMed1988

Comparative studies on Asian and Caucasian children. 1: Growth.

The growth of children whose parents originated from the Indian sub-continent (Asians) was compared with that of indigenous, white children in Rochdale (Caucasians) in a longitudinal study during the first 2 years of life. Reference was made to growth standards currently used in the UK and a small cross-sectional growth study was also carried out on related infants living in Pakistan. With the exception of birthweight, analysis of variance revealed few significant differences in individual growth parameters between the two populations living in the UK.

Body Height↗
PubMed1988

Comparative studies on Asian and Caucasian children. 2: Nutrition, feeding practices and health.

The growth of children whose parents originated from the Indian subcontinent (Asians) and of indigenous, white children in Rochdale (Caucasians) has been related to dietary intake which was estimated by 3-day weighed intakes during a longitudinal study at 3, 6, 9, 12 and 24 months of age. The use of human milk vis-à-vis infant milk formulas, the age of introduction of solid food and the effect of other environmental factors were also evaluated. Multiple regression analysis revealed the effects of diet per se on growth to be fairly minimal; a maximum of 28 per cent of the variation in growth could be explained by diet and the few individual nutrients significantly correlated with a growth index were not consistent.

Breast Feeding↗
PubMed1983

The survival of adult Litomosoides carinii transplanted into cotton rats previously injected with irradiated stage 3 larvae.

Adult Litomosoides carinii were surgically removed from the pleural cavities of normal cotton rats which had been infected 35 days previously by the inoculation of normal stage 3 larvae. Groups of 20 such worms were then transplanted into either the pleural cavities of other normal, uninfected cotton rats or into the pleural cavities of cotton rats which had previously received, by subcutaneous injection, either 3 X 50 L3 which had been exposed to 40 krads Cobalt 60 irradiation or 1 X 50 L3 irradiated at 16.2 krads. Cotton rats vaccinated with irradiated L3 prior to transplant accepted transferred worms for at least 65 days whereas uninfected cotton rats soon encapsulated and destroyed the transferred worms. Microfilariae were detected in the pleural exudate and peripheral blood of vaccinated cotton rats but not in that of unvaccinated cotton rats.

Animals↗
PubMed1982

Vitamin A deficiency and the development of Litomosoides carinii (Nematoda, Filarioidea) in cotton rats.

This paper demonstrates that vitamin A deficient (A-) cotton rats are more susceptible to infection with Litomosoides carinii than normal (A+) cotton rats. However, embryogenesis is frequently retarded in female worms from A- hosts. Groups of young cotton rats were depleted of their liver stores of vitamin A by feeding them a vitamin A free diet from weaning. From 6 weeks of age this diet was supplemented with either 2, 5, 10, 25 or 100 IU vitamin A per 100 g body weight per day and half the animals in each group were infected with L. carinii. At autopsy, 51 days post-infection, serum vitamin A levels were proportional to vitamin A intake but were unaffected by infection (P less than 0.05). A+ cotton rats grew more rapidly and gained more weight than A- ones; infected animals gained less weight than their uninfected controls. More parasites developed in rats fed either 2 or 5 IU vitamin A than those fed either 10, 25 or 100 IU (P less than 0.02) and parasites from the 5 IU group were significantly longer than those from all other groups (P less than 0.02). However, microfilarial development was retarded in female worms from A- animals as compared with A+ ones.

Animals↗
PubMed1982

The host-parasite relationships in normal and protein-malnourished cotton rats infected with Litomosoides carinii (Nematoda: Filarioidea).

A total of 120 young cotton rats were fed ad libitum for 10 weeks on either synthetic diets containing 2.5, 5, 10 or 15% casein or on a stock breeding diet containing 20% crude protein. Half of the animals in each group were infected with the filarial nematode Litomosoides carinii and the food intake and body weight of each animal was measured. There was a trend towards increased food consumption in protein-deficient cotton rats and this was increased further in infected animals; however, differences between groups were not significant. Low protein diets reduced the rate of growth of uninfected and infected cotton rats; filarial infection intensified these adverse effects of under-nutrition and increased the number of rats which died in the lowest protein group. Protein deficiency had little effect on the number of L. carinii which developed, although fewer parasites became established in cotton rats fed on a 2.5% diet than in those fed on a 10% diet. Parasites developing in protein-deficient animals were shorter than those developing in well-fed ones and embryogenesis was retarded in female worms from protein-deficient animals. The onset of patency was retarded in protein-deficient animals and the microfilaraemia which developed subsequently was lower up to 120 days post-infection.

Animals↗
PubMed1982

The development of normal and gamma-irradiated Litomosoides carinii larvae in cotton rats.

The development of infective, stage 3 larvae of Litomosoides carinii irradiated at either 2.7, 5.4, 10.8, 16.2, 21.6 or 40 krads in a cobalt 60 source was compared with that of normal larvae following injection into cotton rats. Worm recovery decreased as the radiation dose increased, male worms being more affected than female worms. Worms developing from irradiated larvae were shorter than normal and at 16.2 krads and above they failed to develop into adults despite reaching the pleural cavity and moulting to stage 4 larvae. Development had ceased by 35 and 20 days post infection for larvae irradiated at 21.6 and 40 krads respectively. 10 krads and below allowed larvae to moult into adults but they were stunted and retarded developmentally. Microfilariae were absent from the pleural cavity and peripheral circulation of all cotton rats injected with irradiated larvae.

Animals↗
PubMed1982

Vaccination of Jirds, Meriones unguiculatus, against Litomosoides carinii and Brugia pahangi using irradiate larvae of L. carinii.

This study has shown tht exposure of jirds to radiation-attenuated larvae of one filarial species confers resistance to another species and thus indicates the potential for developing zooprophylactic regimens for the control of human filariasis. 13 and 8 Meriones unguiculatus were vaccinated with infective 3rd stage larvae of Litomosoides carinii attenuated by 40 krad Cobalt 60 irradiation and challenged with either L. carinii or Brugia pahangi respectively. Vaccinated jirds showed a 98% reduction in the expected challenge of L. carinii and a 71% reduction in the expected challenge of B. pahangi when compared to infectious in non-vaccinated controls.

Animals↗
PubMed1981

Shared antigens between Litomosoides carinii and its hosts Sigmodon hispidus and Mastomys natalensis.

Using a indirect immunofluorescent technique it has been shown that host or host-like antigens are present on adults and microfilariae of Litomosoides carinii from cotton rats and multimammate rats. Red blood cell components were seldom detected on any stage but serum antigens were found associated with the cuticle of adults worms. Serum components were absent from in utero and in vitro microfilariae but were found on microfilariae from pleural exudate and host blood. These components were lost from microfilariae after their ingestion by the vector, were absent from third and fourth stage larvae but reappeared as the adults matured in the pleural cavity of a new host. Countercurrent immunoelectrophoresis showed that the components had alpha 2--beta 1 and beta 1--beta 2 mobility.

Animals↗
PubMed1980

Suppression of microfilaraemia in Litomosoides carinii infections in cotton rats by vaccination with adult worm homogenate.

Twenty cotton rats were injected with a homogentae of adult male and female Litomosoides carinii prepared by freeze-thawing the worms in phosphate-buffered-saline followed by mechanical treatment in a Potter-Elvejhma homogenizer. Intramuscular injections including Freund's complete adjuvant were made into rats which were subsequently quantitatively exposed to infection with L carinii in Liponyssus bacoti. There was no development of a microfilaraemia between 50 and 100 days post-infection in any of the 'vaccinated' cotton rats despite the presence of living adult male and female worms and microfilariae in the pleural cavity. In all the control animals and microfilaraemia developed which persisted for up to 100 days after infection.

Animals↗
PubMed1976

Host-parasite relations in cotton rat filariasis. I: The quantitative transmission and subsequent development of Litomosoides carinii infections in cotton rats and other laboratory animals.

This paper introduces the long-term and continuing studies of the authors and their colleagues on several aspects of the host-parasite relations in cotton rat filariasis. Five methods are described for the calculation of the number of infective larvae of Litomosoides carinii transmitted to cotton rats and other laboratory animals by groups of Liponyssus bacoti mites. The relation between the calculated transmission intensities and the number of worms recovered from individual infected animals has been determined by each of the five methods. The accuracy and relevance of each method is discussed and one (method B) has been found to give a better correlation with worm recovery than the others. Some effects of infection with filariasis on the mites are described. The role of heavily infected mites in transmission is questioned and their influence on the calculation of transmission is discussed.

Animals↗
PubMed1975

1. The effect of dietary fat on the host-parasite relations in cotton rat filariasis. 2. Host-parasite relations in the progeny of cotton rats fed protein deficient diets and infected with filariasis-a preliminary report. 3. Immunoglobulin levels in the early stages of infection with filariasis in cotton rats with and without dietary protein deficiency. 4. Action of aliphatic alcohols on aquatic stages of mosquitoes.

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Alcohols↗