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Biomedical subjects

D M Sukul

Publications and source records attributed to D M Sukul.

7 recordsLinked to original sources
PubMed1994

Effects of high-energy shockwaves on normal human fibroblasts in suspension.

To gain insight in the effects of shockwaves on human cells the relationship between the energy density and the number of shockwaves as well as their effect on suspensions of normal cells was studied. At energy densities of 0.37, 0.6, 0.78, and 1.20 mJ/mm2 fibroblasts were subjected to 50, 100, 250, 500, and 1,000 shockwaves. Each test was performed three times and one sample was used as control. A decrease in viability related to the logarithm of both the number (P = 0.0000) and the energy density (P = 0.001) of the shockwaves was statistically demonstrable 1 hr after the shockwave application. The energy density of the shockwaves has less influence on the viability than the number of applied shockwaves. Seeding of viable cells 1 hr after the shockwave application showed that the decrease in the 48-hr growth potential was statistically dependent of the number of applied shockwaves only (P = 0.0007). After 24 hr no difference in the 48-hr growth potential could be demonstrated between viable shockwave-treated cells and control cells. The literature as well as our own investigations in vitro and in vivo indicate that shockwaves have a logarithmic dose-dependent destructive effect on cells in suspension, but they also seem to have a dose-dependent stimulating influence on the healing process in damaged tissues. Due to the logarithmic relationship between the viability and both the number and energy density of the applied shockwaves it might be expected that even excessive numbers of high-energy-density shockwaves don't soon lead to total destruction of all cells in the suspension.(ABSTRACT TRUNCATED AT 250 WORDS)

Cell Line↗
PubMed1993

Controlled trial of a semi-rigid bandage ('Scotchrap') in patients with ankle ligament lesions.

A randomized, controlled, parallel-group study was performed to compare the clinical efficacy of a semi-rigid bandage ('Scotchrap') with the standard adhesive tape treatment for ankle ligament injuries. The semi-rigid bandage support wrap consists of a knitted fibreglass fabric impregnated with a polyurethane resin. The cotton stockinet and the synthetic cast padding are used for protection of pressure points and any bony prominences. Prior to application, the 'Scotchrap' must be soaked in water after which it is applied in a way similar to that used for a plaster of paris bandage. The finished bandage remains elastic, allowing normal dorsal and plantar flexion of the foot, but preventing inversion and eversion, and pronation and supination. At rest, the bandage always redresses the immobilized ankle into the neutral position. One hundred and thirty-six patients were included in the study. The semi-rigid bandage group comprised 59 patients and the tape group had 57 patients. These two groups were statistically comparable. The intake questionnaire included a general and a specific anamnesis form as well as a physical examination form. Follow-up data were recorded every 2 weeks. After termination of the treatment, the patients evaluated treatment efficacy. Statistical analysis of 126 items per patient with chi 2-tests (p < or = 0.05) and Fisher's exact tests (p < or = 0.05) revealed no statistical significant differences in treatment result. The patient assessments of treatment efficacy of both types of bandage were also comparable. Both types of bandage gave sufficient stability (98%; p < 0.005) and were equally effective.(ABSTRACT TRUNCATED AT 250 WORDS)

Adhesives↗
PubMed1991

Sixty-three cases of traumatic injury of the diaphragm.

In the examination of patients with severe thoracic and/or abdominal trauma not requiring surgical exploration, special attention should be given to signs of traumatic diaphragmatic herniation (TDH). We analysed the hospital records of 63 patients with traumatic injuries of the diaphragm. Of these patients, 39 had suffered a blunt trauma in a traffic accident, 21 penetrating trauma, and three had fallen from a great height. There were 51 patients (81 per cent) with left-sided diaphragmatic injuries, ten (16 per cent) with right-sided injuries, and in two patients (3 per cent) the injuries to the diaphragm were bilateral. There were 22 patients (35 per cent) who had intrathoracic migration of abdominal viscera. Surgical treatment was given in all cases. Twelve patients (19 per cent) died due to massive haemorrhage, neurological lesions, or septicaemia. Based on the literature and our own experience, we developed a diagnostic protocol for the management of diaphragmatic injuries. Chest radiographs should be made routinely. If diaphragmatic injury is suspected, ultrasound investigation must be performed. If the physician is still in doubt, computed tomography should be performed. At laparotomy, the diaphragm should always be thoroughly examined for lacerations.

Abdominal Injuries↗
PubMed1990

Anterior sternoclavicular dislocation: a long-term follow-up study.

The long-term follow-up results of 13 patients with traumatic anterior sternoclavicular dislocations are described. The patients had a mean age of 36.2 (SD 17.9) years. Nine patients had serious concomitant injuries. Radiological examination had limited diagnostic value. For 12 patients, nonoperative treatment consisted of analgesics and immobilization. The results of treatment of 10 patients were evaluated after a mean follow-up period of 62.9 (SD 53.4) months. The results of treatment were good in seven patients, fair in two patients, and poor in one patient. We concluded that radiological examination has a limited value in diagnosing anterior sternoclavicular dislocations and that nonoperative management is the treatment of choice.

Adolescent↗
PubMed1989

Sharp thoracic injury.

In an effort to develop effective rules for the management of penetrating thoracic injuries, all records of 515 patients treated for sharp chest injuries between 1961 and 1985 at the University Hospitals of Amsterdam (Binnengasthuis, Wilhelmina Gasthuis and Academic Medical Centre), were reviewed. The analysis reveals that of these patients 321 (62 per cent) could be treated conservatively, because of a non-penetrating injury, while 140 had a penetrating injury, of whom 77 had to be operated on. Eleven patients died (2.1 per cent). Data concerning these patients are discussed separately. Based on our analysis, and supported by recent literature, an aggressive approach towards penetrating thoracic injury in haemodynamically unstable patients is justified.

Adolescent↗