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Biomedical subjects

D M Valerino

Publications and source records attributed to D M Valerino.

11 recordsLinked to original sources
PubMed1978

Interaction of pargyline with rat hepatic microsomes.

When administered by intraperitoneal injection daily for 3, 7 or 14 days, pargyline (75 mg/kg) significantly reduced rat hepatic microsomal ethylmorphine N-demethylase activity and cytochrome P-450 content. Injection of a lower dose of pargyline (15 mg/kg) failed to alter significantly either ethylmorphine N-demethylase activity or cytochrome P-450 content. Studies performed in vitro reveal that pargyline is metabolized to at least three compounds by rat hepatic microsomes. Thin-layer chromatography and other analyses suggest that one metabolite is an N-demethylated form, norpargyline.

Animals↗
PubMed1978

Occupational pharmacology.

Occupational pharmacology is defined as a subdiscipline important to occupational safety and health, in which specialized information is gathered and evaluated. Occupational pharmacologist study and evaluate drugs used to combat or prevent occupational diseases. They also perform studies on occupational chemical-drug interactions. Specialized training programs are needed to produce qualified individuals for expected future needs.

Drug Interactions↗