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Biomedical subjects

D M Whitelaw

Publications and source records attributed to D M Whitelaw.

11 recordsLinked to original sources
PubMed1971

Hemoglobin values in aged men.

To determine whether the level of hemoglobin declines with age a group of 92 aged males averaging 81 years was carefully examined to exclude disease likely to cause anemia or polycythemia. Arterial blood was drawn from each patient before he was allowed out of bed in the morning to avoid the hemoconcentrating effect of the erect posture. The mean hemoglobin concentration was 12.9 +/- 1.5 g.% and the values were distributed normally. There was a decline of hemoglobin concentration with age which is probably nonlinear since it becomes more marked in the very old. The decline is thought to be part of the aging process and not a manifestation of disease.

Age Factors↗
PubMed1970

A comparison of nitrogen mustard and vinblastine sulfate in the treatment of patients with Hodgkin's disease.

In a crossover study the effectiveness of intermittent maintenance doses of nitrogen mustard was compared to that of vinblastine sulfate in the treatment of 61 patients with advanced Hodgkin's disease. Forty-five of the patients had had previous radiation therapy. Nine of 29 patients who received nitrogen mustard as the first drug had a complete response and five had a partial response. The comparative results in 32 patients receiving vinblastine sulfate first were nine complete responses and 13 partial responses. The median duration of the complete responses to each drug was 43 weeks. The partial responses were of shorter duration. When the second drug was given in adequate doses, almost as many patients responded with a similar median duration of response.It is concluded that nitrogen mustard and vinblastine sulfate are equally effective single agents in the treatment of patients with advanced Hodgkin's disease and that patient preference would favour vinblastine sulfate because of its negligible side effects.

Adolescent↗
PubMed1966

The relation between lymphosarcoma and leukemia.

Of 283 cases of lymphocytic disease, 81% fell within three distinct categories: lymphocytic and lymphoblastic lymphosarcoma and lymphocytic leukemia. The remaining 19% showed transitions from more mature to less mature cell types or from local to general anatomic distribution. The clinical course was related to the cell type and the extent of disease rather than to the presence of blood stream invasion. Survival of patients with lymphocytic leukemia and of those with lymphocytic lymphosarcoma was the same, while that of patients with lymphoblastic lymphosarcoma was much shorter. Survival curves are simple exponentials and do not suggest two populations, one with disease less malignant than the other.

Adolescent↗