PubMed Health⌕ Search

Biomedical subjects

D M Whiting

Publications and source records attributed to D M Whiting.

10 recordsLinked to original sources
PubMed2001

January 2001: A 37 year old man with a history of Hodgkin's disease.

The January Cases of the Month (COM): A case of intracranial metastatic nodular sclerosing Hodgkin's disease without dural attachment in a 37-year-old previously stage III male is presented with a brief review of the literature. Both the primary tumor in the lymph node biopsy and the metastatic brain tumor showed similar histopathology and a immunohistochemical profile typical for Hodgkin's Disease. After chemotherapy, there are no signs of recurrence or systemic disease on follow-up for five months.

Adult↗
PubMed1998

Prolonged survival in a patient with sinonasal teratocarcinosarcoma with cranial extension. Case report.

Sinonasal teratocarcinosarcoma is a rare malignant neoplasm characterized by the combined histological features of carcinosarcoma and teratoma. The primary symptoms of this tumor are usually nasal obstruction and epistaxis, and a nasal cavity mass is the most common clinical finding. The authors describe an exceptionally rare case in which the patient presented with massive intracranial extension and exhibited confusion as an initial symptom. He subsequently underwent combined radical surgery and radiation therapy and has remained free of disease for 31 months. The surgical approach to the lesion, histological features, and clinical course are detailed.

Aged↗
PubMed1990

Intractable complex partial seizures associated with occult temporal lobe encephalocele and meningoangiomatosis: a case report.

Occult congenital temporal lobe encephalocele has rarely been reported in association with medically intractable complex partial seizures. The four previously reported cases were unsuspected preoperatively. We present the case of an 18-year-old woman with intractable complex partial seizures since age 13. Seizure onset was electrically localized to the right temporal lobe. Preoperative neuroimaging studies revealed a middle fossa defect and inferior herniation of the right temporal lobe. Pathologic examination of the resected encephalocele revealed prominent features of meningoangiomatosis. We believe this to be the first case of temporal lobe encephalocele and epilepsy to be diagnosed preoperatively, and the first case also to be associated with meningoangiomatosis. The relevant literature on meningoangiomatosis and on temporal lobe encephalocele as a cause of epilepsy is reviewed.

Adolescent↗
PubMed1990

Intra-arterial chemotherapy for brain tumors.

Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-1-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as BCNU diluent. When ethanol was used as a diluent, right (infused) hemisphere:left (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs.

Analysis of Variance↗
PubMedDate not supplied

Management of subarachnoid hemorrhage in the critical care unit.

Subarachnoid hemorrhage from a ruptured intracranial saccular aneurysm is associated with a high rate of morbidity and mortality. Most complications occur two to three weeks after the initial hemorrhage. The key to minimizing morbidity and mortality is early and aggressive intensive-care management. The Cleveland Clinic Neurosurgical Intensive Care Unit approach is reviewed.

Clinical Protocols↗
PubMedDate not supplied

Stereotactic biopsy of non-neoplastic lesions in adults.

Stereotactic biopsy of intracranial lesions has been used primarily for the diagnosis of neoplastic lesions. A series of 158 consecutive stereotactic biopsies performed at The Cleveland Clinic Foundation resulted in 28 diagnoses of non-neoplastic disorders (18%). The majority of these were infectious, inflammatory, or demyelinating disorders. Stereotactic biopsy alone was diagnostic in 17 cases (61%), and biopsy in conjunction with clinical and laboratory data established definitive diagnoses in six cases (22%). All 23 definitive diagnoses led to modifications in patient management. Permanent neurologic morbidity occurred in only two patients (7%). We maintain that this procedure is underused. Stereotactic biopsy is safe, accurate, and useful for diagnosis of non-neoplastic neurologic disorders when the diagnosis is unclear by conventional means. In such cases, its use can lead to early diagnosis and treatment.

Adult↗
PubMedDate not supplied

Cervical neurenteric cyst associated with Klippel-Feil syndrome: a case report and review of the literature.

A neurenteric cyst of the spine is a rare congenital disorder secondary to alimentary duplication and vertebral malformation. It should, however, be included in the differential diagnosis of an intradural, extramedullary spinal lesion. We present a case of a cervical neurenteric cyst associated with Klippel-Feil syndrome and discuss the clinical, radiologic, histopathologic, immunohistochemical and embryologic characteristics of this disorder.

Adult↗