Pharmacokinetic system: computer-aided dosing regimens with a new software package.
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Biomedical subjects
Publications and source records attributed to D Möller.
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A group of researchers and educators in The Netherlands, Germany and Czechoslovakia have developed and adapted mathematical computer models of phenomena in the field of physiology and biomedicine for use in higher education. The models are graphical and highly interactive, and are all written in TurboPascal or the mathematical simulation language PSI. An educational shell has been developed to launch the models. The shell allows students to interact with the models and teachers to edit the models, to add new models and to monitor the achievements of the students. The models and the shell have been implemented on a MS-DOS personal computer. This paper describes the features of the modeling package and presents the modeling and simulation of the heart muscle as an example.
The effect of Co 60-irradiation (70 Gy) on pulverized human enamel and synthetic hydroxyapatite was studied in vitro. Irradiated and non-irradiated samples were experimentally demineralized (pH 5.1) during a period of 28 days. In terms of solubility, defined as the equilibrium of saturation, there was no statistically significant difference between irradiated and non-irradiated enamel. However, in terms of solubility rates, defined as the amount of dissolved substance during the demineralization period, irradiated enamel showed a statistically significantly higher solubility rate than non-irradiated enamel. There was no effect of Co 60-irradiation on synthetic hydroxyapatite.
For the conventional X-ray therapy the Röntgenverordnung demands the examination of the dose rate in the radiation beam. The measurements and the results are demonstrated. Over a long period the X-ray equipment shows a constant dose rate. Controls of the technical devices and situations of danger are explained.
The problem of choosing parametric descriptions of the systemic vascular bed suitable for monitoring beat-to-beat changes in peripheral vascular properties is considered. Three simple models with two, three, and five elements are compared, essentially exploiting the Akaike information criterion combined with reasonable requirements for estimate accuracy. Analysis of pressure data, which are either simulated by the five-element model or measured on a mock circulatory system during abrupt changes in peripheral resistance, suggests guidelines for model selection. In particular, the five-element model exhibits very close adherence to physical reality by allowing for reflection, while the classical windkessel model provides the most reproducible estimates.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.