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Biomedical subjects

D Mücke

Publications and source records attributed to D Mücke.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Tuftsin].

Literature review. The tetrapeptide tuftsin (Thr-Lys-Pro-Arg) is cleaved off the carrier IgG molecule enzymatically and stimulates the phagocytic and bactericidal activity of polymorphonuclear leucocytes and macrophages. The action of tuftsin is mediated by specific receptor sites on the surface of these cells. Its antitumor activity has been shown in vitro as well as in vivo. The influence of tuftsin on the major metabolic processes of the cell (hexosemonophosphate shunt; cAMP/cGMP; Ca++-distribution; redox reactions) is the basis of its mode of action.--The feature of tuftsin and its low toxicity make it a useful agent for immunotherapy.

Animals↗
PubMed1984

[Methodologic references for clinical function diagnosis of glomerular permeability selectivity by molecular wight related protein analysis and additional para-aminohippuric acid load].

Glomerular perm selectivity can be approximately estimated from the apparent glomerular protein clearance in terms of molecular weight since the relative protein clearance is approximately identical with the corresponding screen coefficient relation. Systematic relativization of individual protein clearances by reference to albumin (or transferrin) clearance requires the application of special calculations to find out the regression coefficients relevant to functional diagnosis. A PAH load influences tubular protein reabsorption so that the clearance of higher-molecular proteins (IgA alpha 2-macroglobuli, IgM) rises. Taking the changes in protein clearance under renotubular PAH load into account allows a more precise estimation of glomerular permeability to be made, in comparison with protein analyses not using PAH load.

Aminohippuric Acids↗