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Biomedical subjects

D Münnich

Publications and source records attributed to D Münnich.

At least 19 recordsLinked to original sources
PubMed1990

Therapeutic value of Gramurin (oxolinic acid) in Shigella infections and Shigella-negative dysentery syndrome.

A total of 10 Shigella-positive and 10 Shigella-negative dysentery syndrome patients were treated with daily 2-g Gramurin doses for 3 days. Favourable clinical results could be obtained in response to the therapy. The complaints of the patients ceased within 48 hours. Bacterial negativity was recorded on days 3, 4, and 5 after cessation of therapy in Shigella flexneri-positive cases (5 cases), while in case of Shigella sonnei positivity bacterium negativity could be obtained within the abovementioned period in only 3 out of the 5 cases. The presented results of Gramurin therapy in Shigella infections and Shigella-negative dysentery syndrome are virtually congruent with the earlier reported favourable observations of the authors with the drug in these conditions.

Adolescent↗
PubMed1989

Attempt with oral immunobiotherapy (broncho-vaxom) and immunochemotherapy (broncho-vaxom + neomycin) for the elimination of bacteria in symptom-free "other Salmonella" carriers.

Forty-five symptomless "other Salmonella" carriers were treated; stool became negative for Salmonella in 22 of the 25 patients treated with Broncho-Vaxom (88%) and in 16 of the 20 patients treated with Broncho-Vaxom + Neomycin (80%) (who had discharged Salmonella for not longer than one month previously). This result is very favourable when compared to data of references of thoroughly controlled patients according to which 69% was the highest rate of bacterial negativity obtained in the treated patients who discharged "other Salmonellas" for not longer than 1 month. The stool of all 10 patients admitted as symptomless carriers of "other Salmonellas" became negative for bacteria in response to the mentioned therapy (in 6 cases of Group I, and 4 cases of Group II). Treatment was unsuccessful primarily in chronic alcohol addicts and toxicosis cases (13%). The unresponsiveness of the two patients suffering from cholelithiasis and excreting also "other Salmonella" with the bile deserves attention. In such cases the positivity of the bile for Salmonella was a reason for exclusion from the study. Further studies (completed with immunological data) are required to assess the value of Broncho-Vaxom immunobiotherapy, and Broncho-Vaxom + Neomycin immunotherapy.

Adjuvants, Immunologic↗
PubMed1979

Clinical, epidemiological and therapeutical experience with human tularaemia: the role of hamster hunters.

Fifty patients suffering from tularaemia were treated in our department. The most frequent occupation of the tularaemia patients was hamster hunter. The most important source of the tularaemic infection (90%) was the hamster (Cricetus cricetus). We observed the cutano-glandular form in 90% of the patients and internal tularaemia in 10%. The antibiotics used (streptomycin i. m., oxytetracycline and doxycycline per os) were effective.

Animals↗
PubMed1976

Treatment of human leptospira infections with semicillin (ampicillin) or with amoxil (amoxycillin).

Ampicillin (Semicillin) and Amoxycillin (Amoxil) have a strong leptospirocidal effect in vitro and also in vivo. We have tested these drugs on 28 patients suffering from Leptospira infection. The patients generally received per os 3 g Ampicillin (Semicillin) or 2 g Amoxycillin (Amoxil) per day over a period of 6 days. In the groups treated with Ampicillin and Amoxycillin the average durations of fever during the treatment were 1.6 and 1.2 days, respectively. In the first group (Ampicillin) a 'second wave of fever' occurred in one case (5%) and in the second group (Amoxycillin), in 0% (as compared to 22% after treatment with benzylpenicillin). On the basis of our experiences, Ampicillin and Amoxycillin are strongly recommended for the treatment of human Leptospira infections.

Adolescent↗