PubMed HealthSearch

Biomedical subjects

D Maass

Publications and source records attributed to D Maass.

7 recordsLinked to original sources

[Extracorporeal circulatory assistance with centrifugal pumps in postcardiotomy low-output syndrome].

From 6/86 to 5/89 seven out of 1700 (0.4%) open heart patients had to be assisted with centrifugal pumps for postcardiotomy low cardiac output syndrome. In 4 cases a left ventricular assist device (LVAD) was used, one case each had a right ventricular assist device (RVAD), an extracorporeal membrane oxygenation (ECMO) and a biventricular assist device (BVAD) with ECMO and ultrafiltration. The last 3 patients were assisted non-pulsatile without intraaortic balloon counterpulsation (IABP) and no impairment of vital organ function was observed. Four out of 7 patients could be weaned from the assist device after a mean of 30 hours (0.5-48). Three patients became long-term survivors with 2 assisted non-pulsatile. Transesophageal echocardiography (TEE) was used to determine the timing for wean off and was found to be an important adjunct to the monitoring of filling--and systemic pressure.

Adult

[Groin flap plastic surgery using McGregor's method].

The specific advantages of the groin flap to the other axial pattern flaps from the trunk are outlined, followed by a detailed description of the operative procedure and the postoperative management. Based on our experience, the groin flap is an uncritical flap and can be recommended in numerous instances either of primary repair or secondary reconstruction of the injured hand.

Hand Injuries

[Ambroxol, studies of biotransformation in man and determination in biological samples (author's transl)].

15 mg trans-4-[2-amino-3,5-dibromo-benzyl)-amino]-cyclohexanol-hydrochloride (ambroxol, NA 872) was administered i.v. and orally to healthy volunteers. The metabolic pattern in urine and plasma was similar for both routes of administration. Biotransformation reactions are straightforward, yielding two major products of phage I reactions identified as 6,8-dibromo-3-(trans-4-hydroxycyclohexyl)-1,2,3,4-tetrahydro-quinazoline and 3,5-dibromo-anthranilic acid. These metabolites as well as the parent compound are also converted to conjugates, predominantly glucuronides. Quantification of unlabelled ambroxol in biological fluids is achieved by radiochemical derivatisation with 14C-labelled formaldehyde in imitation of the biotransformation.

Administration, Oral

Successful replantation of a hand amputated through the metacarpus.

A successful replantation is reported of a hand completely severed by a circular saw through all five metacarpals. The sequence of primary reconstruction of all important structures beginning three hours after the injury and the functional results eighteen months later are presented.

Adult

The absorption, excretion and metabolic pattern of bromhexine in man after oral and i.v. administration.

The fate of 14C-labelled bromhexine (Bisolvon¿) in man following intravenous and oral administration was studied by investigation of the blood and plasma levels and the excretion profiles. Slight variations observed between the two administration routes are explained by the somewhat different distribution patterns resulting from the different "first path" after oral application (liver) and intravenous injection (tissues).

Administration, Oral