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D MacCulloch

Publications and source records attributed to D MacCulloch.

30 records · Page 2Linked to original sources

In-vitro activity of cefoxitin against recent clinical bacterial isolates.

The susceptibility of 635 clinical isolates of bacteria to cefoxitin was determined. Isolates from the urinary tract showed 97% sensitivity, isolates from infected wounds showed 93% sensitivity and 82% of blood culture isolates were sensitive. Streptococcus faecalis isolates showed only 50% sensitivity and pseudomonas organisms were predominantly resistant. Bacteria isolated from unprepared heart valves submitted for use as homografts showed only 71% sensitivity due to the large proportion of Streptococcus and Pseudomonas species isolated.

Bacteria↗

Endocarditis due to Citrobacter diversus developing resistance to cephalothin.

A 43-year-old man was admitted with acute bacterial endocarditis. Citrobacter diversus susceptible to cephalothin was isolated from blood cultures. Citrobacter diversus was later isolated from the aortic valve cusps at surgery, but this isolate was resistant to cephalothin. Laboratory testing showed that the Citrobacter diversus recovered from blood cultures was capable of producing mutants highly resistant to cephalothin.

Adult↗