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Biomedical subjects

D MacRae

Publications and source records attributed to D MacRae.

13 recordsLinked to original sources
PubMed1990

Auditory function in Duane's retraction syndrome.

We obtained audiograms and auditory brainstem responses from 44 patients with Duane's retraction syndrome to assess the incidence and nature of hearing deficit. Of 44 patients, seven (15.9%) had evidence of hearing impairment. Three (6.8%) subjects had a temporary conductive hearing loss because of middle ear fluid, and another patient had hearing loss from Crouzon's disease. The remaining three (6.8%) patients demonstrated sensorineural hearing deficit. This hearing impairment was attributed to a cochlear lesion and not to a pontine lesion. We believe that the frequency of sensorineural hearing loss in these patients warrants hearing screening programs similar to those used for infants in neonatal intensive care units.

Adolescent↗
PubMed1988

Hemangiopericytoma of the ciliary body.

A 60-year-old woman had a ciliary body tumor that resembled an amelanotic malignant melanoma by clinical examination. The magnetic resonance imaging scan correlated with the clinical diagnosis. Because of apparent rapid growth, her eye was enucleated. However, histopathologic examination revealed a highly vascularized, spindle-cell tumor harboring immunoreactive actin and vimentin. Electron microscopy further supported the diagnosis of hemangiopericytoma with smooth-muscle differentiation. To our knowledge, this is the first report of a hemangiopericytoma of the ciliary body.

Ciliary Body↗
PubMed1988

The variation in cervical hydroxyproline and cervical water with age.

The squamocolumnar junction is frequently not visible in the postmenopausal patient. This study attempts to identify some of the changes in the cervix that may account for this observation. Twenty-four cervical biopsy samples taken at the squamocolumnar junction were analysed for hydroxyproline (collagen) and water content. There was significantly more hydroxyproline (collagen) in the premenopausal woman than the postmenopausal woman. Similarly, there was higher percentage of water in the biopsies in the premenopausal woman than the postmenopausal woman. Further samples obtained deeper in the cervical stroma did not confirm these differences. It appears likely that differences in cervical water and cervical collagen near the surface of the cervix account, at least in part, for the lack of visibility of the squamocolumnar junction in the older woman.

Adult↗
PubMed1986

"Swiss roll" laryngotracheoplasty in young children.

Five children with acquired subglottic stenosis were successfully decannulated utilizing a modification of the Evans and Todd "Swiss roll" technique. Modifications including laryngofissure from within the lumen, midline tracheocricoid incision, and posterior cricoid cartilage split seem to be beneficial. There are still problems with postoperative granulations.

Child, Preschool↗
PubMed1981

Cochleo-saccular degeneration in one of three sisters with hereditary deafness, absent gastric motility, small bowel diverticulitis and progressive sensory neuropathy.

This is a report of cochleo-saccular degeneration found in temporal bones from a patient who had suffered from slowly progressive and total sensorineural deafness which had an inherited origin. At age 8, this patient began to complain of hearing loss, and by age 10 she was totally deaf. The patient was 1 of 3 female siblings who have suffered from an exactly identical progressive disease: deafness, absent gastric motility, small bowel diverticulitis and ulceration, and sensory neuropathy. The temporal bone pathology found in this case was the degenerative change in the cochlear duct and sacculus. No pathology was found in the utriculus and semicircular canals.

Adolescent↗
PubMed1980

Use of computer assisted tomography in the diagnosis of lesions in and around the sphenoid sinus.

The use of the CT scanner and its contribution to the diagnosis of lesions in and around the sphenoid sinus has been reviewed. The usefulness of this new imaging technique is discussed. Five representative cases demonstrating special diagnostic tests in conjunction with the CT scanner are discussed. The CT scanner combines low cost with minimal risk to the patient. It is a valuable tool in the investigation of the sphenoid sinus.

Adult↗
PubMed1976

Laryngeal papillomatosis in children.

Thirty-one cases of juvenile papillomatosis of the larynx treated in the Department of Otolaryngology at the Hospital for Sick Children are reviewed. The incidence, pathology, and etiology of laryngeal papillomata are described. Various types of treatment reported from the literature are discussed. Favorable results have been attained by careful frequent endoscopic removal of papilloma lesions using forceps, the cryoprobe, or the carbon dioxide laser. With the use of the operating microscope, the tumor population is reduced and this may allow the circulating antibodies to be more effective on the residual tissue. Tracheotomy is avoided unless near obstruction is present. Decannulization is not advisable until the danger of obstruction from regrowth of the tumor is passed.

Bronchoscopy↗
PubMedDate not supplied

Regulation of p105wee1 and p34cdc2 during meiosis in Schizosaccharomyces pombe.

Temperature-sensitive pat1 mutants of the fission yeast Schizosaccharomyces pombe can be induced to undergo meiosis at the restrictive temperature, irrespective of the mat1 configuration and the nutritional conditions. Using a combination of exit from stationary phase and thermal inactivation of the 52-kilodalton protein kinase that is encoded by the pat1 (also called ran1) gene, highly synchronous meiotic cultures were obtained. Synthesis and tyrosyl phosphorylation of p34cdc2 was evident during meiotic G1 and S phases. During this period there was increased expression of p105wee1, a protein kinase implicated in the tyrosyl phosphorylation of p34cdc2. Following a relatively brief G2 period, during which a reduction in the steady-state level of p105wee1 occurred, there was an approximately 19-fold increase in the histone H1 phosphotransferase activity of p34cdc2. Only a single peak of histone H1 kinase activation was observed, which implies that unlike meiosis in amphibians and echinoderms, p34cdc2 is functional only during one of the meiotic divisions in S. pombe, presumably meiosis II. Stimulation of the kinase activity of p34cdc2 was associated with its tyrosyl dephosphorylation. This is analogous to mitotic M phase and suggests parallels in the mechanism of activation of p34cdc2 during mitosis and one of the meiotic divisions in S. pombe.

Amino Acid Sequence↗