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Biomedical subjects

D Mainard

Publications and source records attributed to D Mainard.

49 records · Page 3Linked to original sources
PubMed1992

[Risk of infection related to the use of cryopreserved bone grafts from domestic banks].

The authors report their experience of a home bone bank of cryopreserved femoral heads on a period of 3 years. They remind the rules to observe for the harvesting, the storage and the utilization of these allografts, and also the indispensable biological tests (at the moment when the article was written). About their series, the authors remind the risks of infection in relation with the utilization of femoral head from bone bank, which justify a great rigour in the organization and the managing of these home bone bank.

Bone Transplantation↗
PubMed1991

Tenoxicam concentrations in synovium and joint cartilage in humans.

Tenoxicam is an NSAID of the oxicam group. Its distribution in articular tissues was investigated in 12 patients who required total arthroplasty of the hip. They were given tenoxicam 20 mg once daily for 8 to 30 days before surgery. Blood, synovium and cartilage samples were taken concurrently during surgery, about 14 hours after the last tenoxicam dose. The tissues were ground using a freeze grinder. Tenoxicam was assayed by HPLC. Tenoxicam concentrations averaged 6.21 +/- 3.81 micrograms/ml in plasma, 7.56 +/- 4.67 micrograms/g in synovium and 2.05 +/- 1.43 micrograms/g in cartilage. The individual synovium/cartilage ratios ranged from 1.9 to 9.7. Finally tenoxicam exhibited more affinity for its target organ (synovial tissue) than for joint cartilage.

Adult↗
PubMed1991

[Ulnar nerve compression at the elbow caused by synovial cyst of rheumatoid origin].

The authors report on a case of a fifty year old white woman affected by a rheumatoïd arthritis of 3 year duration who develops a progressive ulnar nerve compression by a synovial cyst of the right elbow joint. Surgical procedure confirms the articular and rheumatoïd origin of the synovial cyst and obtains complete healing of the motor and sensory deficit without recurrence of the synovial cyst. Synovial cysts are rare at the elbow joint where they cause as an exception a compression of the ulnar nerve, the authors having found only five cases in the literature.

Arthritis, Rheumatoid↗
PubMed1991

[Study of loosening and wear of total hip prosthesis. Apropos of a series followed-up over 10 years].

After reviewing 30 cases of patients having had a total hip arthroplasty by the Charnley's technique between 1970 and 1978, the authors study the radiographic parameters of the cup and of the femoral stem, using geometric buildings described by Sutherland. On the acetabulum, the inclinaition angle, the medialisation and the wear of the cup were calculated. The varisation of the stem and its migration were looked for on the femur. The presence of a radiolucent line, prosthesis--bone or cement--bone and the importance of peri-articular calcifications, was also noted. The verticalisation of the cup and its anteversion were a pejorative factor. The medialisation was disquieting only if it was associated with a verticalisation. The wear more than 2 mm was noted only in 5 cases; the radiolucent line was pejorative only if it was type cement--bone; the type cement--cup, rare, was of less bad prognostic. On the femur, the most failing was the varus of the stem which determined a loosening most often when it was present. The disquieting radiolucent line was always type cement--bone and was always associated with a bicortical reaction showing a mobility of the stem. In a last part, the authors studied the wear of expanted cups in polyethylene which was different of the fluage. A distinction between the theoretical wear and the clinical wear was made. Photographs in scanning electron microscopy which permit to describe the different types of wear are presented.

Adult↗
PubMed1989

Laser-Doppler versus fluorometry in the postoperative assessment of a cutaneous free flap.

To find the optimal means for monitoring the vascularity of a cutaneous free flap in the postoperative period, we have experimentally compared laser-Doppler velocimetry and fluorometry. Using the rat groin model, five groups were evaluated: 1. flap isolation without division of the pedicle vessels (island flap); 2) flap isolation, division, and repair of the pedicle artery and vein (free flap); 3) flap isolation, with ligation of the pedicle artery immediately or 1 hour later; 4) flap isolation, with ligation of the pedicle vein immediately or 1 hour later; 5) flap isolation, with ligation of the pedicle artery and vein immediately or 1 hour later. The laser-Doppler processes the signal by combination of the root mean square and differential amplification. The fluoroscan gives an index in relation to the fluorescence of a control area. The results obtained with both methods correlated well with findings in clinical situations. However, the laser-Doppler readings were more rapid and sensitive than those with fluorometry. We suggest that laser-Doppler velocimetry is a superior means of monitoring the vascular status of a free tissue transfer or digital replant.

Animals↗
PubMed1989

[Value of the scanner for diagnosing synovial cysts of the hip. Apropos of 2 cases. Review of the literature].

Two cases of synovial cysts of the hip have been observed by the authors. They were extending anteriorly and were developing from the psoas iliac muscle bursa. After a review of the literature it is concluded that this is a rare condition, and that CT scan made the diagnosis much easier. In one case the cyst complicated a rheumatoid arthritis, in the other the origin was not clear. The clinical features and differential diagnoses are recalled.

Aged↗
PubMed1986

Gastric stress ulcer of the rat: relative contribution of the pyloric sphincter, HCO3- bile reflux and mucosal blood flow.

Gastric ulceration has been induced after stress, combining 24 h of fasting and 48 h of restraint in 9 groups of 20 rats with or without a pyloroplasty or a pylorojejunostomy combined with atropine and gastric infusion of NaHCO3 or taurocholic acid. After death or sacrifice at 48 h, ulcer index and blood in the jejunum were determined. Gastric mucosal blood flow was measured semi-continuously by a laser Doppler velocimeter. There were 45% deaths after 48 h of restraint alone, and 70% in the group combining pylorojejunostomy with taurocholic acid. Mortality was lower (p less than or equal to 0.01) pylorojejunostomy alone and more significantly so (p less than or equal to 0.001) when associated with NaHCO3. There was no death when NaHCO3 and atropine were combined with restraint. The mucosal blood flow increased significantly during the first 12 h of restraint in the taurocholic acid group. Both groups with NaHCO3 had mucosal blood flows similar to the controls. Gastric acid and gastric emptying, mucosal ischemia and bile reflux are joint factors inducing gastric stress ulcer. The 100% survival and the low ulcer index after a treatment by atropine and gastric infusion of NaHCO3 suggest that these well-known drugs should be used more frequently.

Animals↗
PubMed1985

[Osteoarthritis in infants. Follow-up and treatment].

For 25 years, 102 hematogenous septic arthritis have been observed in 82 newborns and infants. The hip joint was the most commun site of involvement (63 cases), than the knee (23 cases), the shoulder (7 cases), the elbow (5 cases), the ankle (3 cases) and one wrist. 14 times, two or more joints were involved. When the diagnosis was made early, an aspiration of pus and an irrigation of the joint was done. But in severe and delayed arthritis, an arthrotomy was preferred. In all cases, joints were immobilized in a post-operative cast or with a traction management, and parenteral antibiotics were prescribed. 52 sequellae were noted, two third of these were seen in second hand. Sequellae are detailed joint by joint, and the authors describe different stages from minor dysplasia and abnormal growth of the epiphysis to severe destruction of the bones and persistent dislocation. Treatment of sequellae is proposed: 1. The hip joint. Dysplasia and deformities of the head and/or the neck were corrected with femoral osteotomy. In 2 cases, a pelvic innominate osteotomy was performed. Progressive coxa vara with short neck and greater trochanteric overgrowth were treated with femoral neck lengthening (personal technic). Dislocations needed open reduction of the hip and extensive excision of the acetabular fibro-fatty tissue. In a few cases, a Colonna's procedure was made. In total destructions of the upper femoral extremity, the treatment consisted in trochanteroplasty. In partial epiphysiodesis of a femoral condyle, disepiphysiodesis was obtained with resection of the physeal bone bridge (2 cases) or with free free physeal transplantation with microvascular anastomosis (2 cases).(ABSTRACT TRUNCATED AT 250 WORDS)

Arthritis, Infectious↗
PubMedDate not supplied

An unusual case of hip septic arthritis due to Bacteroides fragilis in an alcoholic patient.

We describe a 53-year-old alcoholic man who presented with hip septic arthritis due to Bacteroides fragilis. This arthritis involved a severe destruction of the femoral head, which was completely devitalized. Recovery was achieved after 4 months of antimicrobial therapy with imipenem/cilastatin plus metronidazole, surgical debridement of the necrotic tissues and four sessions of hyperbaric oxygen.

Alcoholism↗
PubMedDate not supplied

Use of supercritical fluid extraction as a method of cleaning anterior cruciate ligament prostheses: in vitro and in vivo validation.

The process of supercritical fluid extraction (SFE) using carbon dioxide as the mobile phase is finding increasing numbers of applications in a wide variety of industries for the extraction, separation, and cleaning of materials. This study assessed the usefulness of this approach in removing surface contaminants from a knitted polyester anterior cruciate ligament (ACL) prosthesis before packaging and sterilizing the product during manufacture. The physical, dimensional, and chemical properties of SFE treated compared with commercially scoured control samples were characterized using a number of textile test methods: electron spectroscopy for chemical analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and solvent extraction analysis. The biocompatibility of the samples was measured in terms of their ability to generate CD18 integrin expression on activated human polymorphonuclear cells, and their inflammatory response when implanted for up to 30 days in the knee joint of rats. SFE treatment was successful in removing most of the nonpolar contaminants from the ACL prosthesis and reducing the amount of residuals to a commercially acceptable level. However, some nitrogen containing compounds and polar salts were not removed by the SFE process. The results from the biocompatibility tests demonstrated that the cleaner SFE treated prosthesis induced significantly lower CD18 expression than the scoured control fabric, and was also associated with a milder inflammatory response and a more rapid rate of healing during the 30 day animal trial. Another effect of SFE processing was to cause the polyester device to shrink and lose porosity because of yarn contraction and modification of the polymer's microcrystalline structure.

Animals↗
PubMedDate not supplied

[Ideal total hip prosthesis in 1993].

Although it is a hazardous adventure to define what is an ideal in any field, it would appear that there is a certain consensus about total hip prostheses. The fundamental principle of the total hip replacement was based on the articulation of a spheric segment, a mobile head contained in a hemispheric non-retaining element. To date, the first material is a titanium in a alloy containing 6% aluminum and 4% vanadium. The second material facing the titanium is polyethylene or alumine. Thus the joint couple could be "polyethylene-metal", or "polyethylene-alumine" or even "alumine-alumine". The hemispheric element can be a massive piece of polyethylene or formed by a peripheral metal (an open hemisphere) filled with the joint surface, itself made of polyethylene. This solution offers the possibility of changing the prosthesis in case of wear without interrupting the implant-bone contact. The first type is cemented to the bone with methyl polymethacrylate. With the second, the metallic part need not to be cemented and can be fitted to the bone by simple pressing. Several points are essential in the femoral piece. It should include a removable head so the length of the neck can be adjusted. It must fill the medullary canal as closely as possible and fill the methaphyseal space. It is fixed by a self-fitting system leading to stable secondary long-term fixation-a porous covering, sometimes with hydroxy apatite can also be useful. In certain cases it must be cemented, although the cement must only play the role of adaptation.(ABSTRACT TRUNCATED AT 250 WORDS)

Biocompatible Materials↗