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Biomedical subjects

D Malvy

Publications and source records attributed to D Malvy.

92 records · Page 6Linked to original sources
PubMedDate not supplied

[Prevalence of endemic goiter in the health sector of Zitenga (Burkina Faso)].

The prevalence of iodine deficiency disorders (IDD) was studied in the health district of Zitenga village (Oubritenga province, Burkina Faso), as part of an assisted development program. The study was designed to assess the prevalence of IDD in a population of more than 2,000 people. A multistage cluster sample of 210 people was randomly selected. The women in the sample were aged 0 to 45 years and the men, 0 to 25 years. Clinical and laboratory results (circulating TSH concentration, T4 and iodine excretion in urine), and dietary intake were recorded. The prevalence of goiter (all grades) was 55.2%. The values recorded for iodine excretion in urine showed that there was moderate iodine deficiency in this area. Blood thyroxine levels were below the laboratory reference range for 63% of the subjects, whereas TSH levels were above the laboratory reference range for 69.3% of the subjects. There was no correlation between hormone status, iodine excretion and goiter. The entire population of this area was deficient in iodine; some individuals had clinical signs of iodine deficiency, such as goiter. Further studies are required to investigate the factors responsible for goiter in this area and iodine supplementation should be provided for the population.

Adolescent↗
PubMedDate not supplied

[Ciprofloxacin in the treatment of dysentery caused by type 1 Shigella dysenteriae during an epidemic in Rwandan refugees in Goma in 1994].

There was an outbreak of dysentery caused by type I Shigella dysenteriae among Rwandan refugees at Goma, in what was then Zaire, in 1994. The causal organism was resistant to all antibiotics available from the public health authorities. The only effective antimicrobial agent available was ciprofloxacin. It was given to 326 inpatients at the Médecins Sans Frontières (MSF) Center, mostly children under the age of 5, pregnant women and immunocompromised patients. A standard dose schedule was used: 1 g ciprofloxacin per day in two doses for 5 days for adults, 250 mg for children weighing less than 20 kg and 500 mg for children weighing less than 50 kg. The treatment was effective in 285 patients (85.6%) according to clinical criteria. Treatment was unsuccessful in 6 patients and 14 decided to stop taking the medication although it was having a positive effect. No side effects clearly caused by the treatment have been reported. This is consistent with previous reports showing that ciprofloxacin is clinically effective against epidemic dysentery caused by multi-drug resistant Shigella dysenteriae type I. However, fluoroquinolones are expensive and difficult to obtain and their use would require improvements in logistics and compliance.

Adolescent↗