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Biomedical subjects

D Marić

Publications and source records attributed to D Marić.

83 records · Page 5Linked to original sources
PubMedDate not supplied

[The effect of therapeutic plasma exchange on serum immunoglobulins and the clinical course of myasthenia gravis].

Fourteen patients with clinically, pharmacologically and electrophysiologically confirmed myasthenia gravis in which therapeutic plasma exchange was performed were analyzed. Condition of these patients was assessed before and after the plasma exchange using the Besinger score. The serum immunoglobulin levels were also determined by ELISA-test before and after the plasma exchange. Findings have shown that clinical improvement was highly significant. Changes in IgM and IgA levels were significant, but not in IG and IgE. Significant correlation neither between the level of each separate immunoglobulin and clinical condition of the patient, nor between the change in the level of each separate immunoglobulin and changed clinical course was found after the series of plasma exchange. Cumulative effect of all immunoglobulins was not observed due to differences in their physical and chemical properties. Absence of significant statistical correlation between the level of each immunoglobulin and clinical condition of the patient as well as between the level changes of each separate immunoglobulin and changed clinical condition after series of plasma exchange could be explained by cumulative effect of all immunoglobulins, but probably also by the presence of some other, circulating factor not belonging to the class of immunoglobulins and associated with the development of myasthenic weakness.

Adult↗
PubMedDate not supplied

[Sensitivity of electrophysiologic tests in the diagnosis of carpal tunnel syndrome].

According to anatomic characteristics of median nerve branches and pathophysiological basis of the carpal tunnel syndrome (CTS), significant difference in sensitivity of some electrophysiological parameters in the diagnosis of this syndrome was presumed. The aim of this study was to analyze characteristics of some abnormalities of electrophysiological parameters and to determine their frequency in the carpal tunnel syndrome. Investigation was performed on 34 patients with the carpal tunnel syndrome and 30 neurologically healthy subjects. EMGs of the tenar muscles, terminal latency parameters for the median nerve and sensory conductivity of the median nerve branches including cutaneous palmar branch and ulnar nerve branches of the ring finger were examined and analyzed. Results have shown that abnormalities were most frequently found in sensory conductivity parameters for median nerve branch of the ring finger. Significant difference between sensory conductivity parameters for cutaneous palmar branch and median nerve branch of the thumb was also found. These results were discussed in terms of current knowledge about anatomic characteristics of the hand innervation and pathophysiology of the carpal tunnel syndrome. It was concluded that the most frequent physiological findings could be used as a highly sensitive test for reliable and early diagnosis of CTS.

Adult↗
PubMedDate not supplied

[Sensitivity of atherosclerosis indices in patients with ischemic brain disease].

Epidemiological studies suggest that dyslipoproteinemias and hyperlipoproteinemias present one of the most important risk factors in the development of atherosclerosis and its complications. The aim of this study was to find out which of the lipid status disorders in patients with ischemic brain disease was the most important risk factor in the development of cerebral atherosclerosis. Patients with ischemic brain disease were examined in the acute and subacute phase. Total blood cholesterol, low density lipoproteins (LDL) and high density lipoproteins (HDL) as well as of apolipoproteins A1 and B were determined. Correlations (atherogenic indices) of some lipid components with the severity of clinical course and echo-angiographic finding were determined. It was concluded that the highest correlation with the cerebral atherosclerosis severity degree existed with the level of apoA1 and apoB apolipoproteins, followed by correlation of LDL and HDL cholesterol, and the lowest correlation was found between HDL and the total cholesterol. Accordingly, apolipoproteins, i.e., apoA1/apoB indices are the most sensitive markers of the risk for atherogenesis.

Apolipoproteins↗
PubMedDate not supplied

[Diagnostic and prognostic significance of long latency reflexes, somatosensory evoked potentials and the blink reflex in cerebral ischemia].

In order to determine diagnostic and prognostic value of long latency reflexes, blink reflex and somatosensory evoked potentials in patients with ischemic brain disease (IBD), examinations were done in 32 patients of both sexes with IBD, average age 44-76 years. First examinations were performed within first week of the onset of IBD and in majority of patients repeated after 3 and 6 months. Changes of electrophysiological characteristics compared with the degree of IBD, clinical presentation, localization, extent of infarction zone (measured by CT) and functional recovery where analyzed. Electrophysiological changes were predominantly associated with amplitude of physiological response and were in correlation with the degree of IBD, localization and the extent of infarction zone. Latencies were prolonged only in case of subcortical ischemic lesions. Correlation between functional recovery and electrophysiological changes was present only within the structures responsible for certain components of electrophysiological responses and localization of ischemic lesion. In conclusion, electrophysiological examinations are of high diagnostic and predictive value in IBD.

Adult↗