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Biomedical subjects

D Mayeux

Publications and source records attributed to D Mayeux.

32 records · Page 2Linked to original sources

[Catamenial hemoptysis caused by bronchopulmonary endometriosis].

The thoracic localization of endometriosis may involve the pulmonary pleura and the diaphragm, or the bronchopulmonary parenchyma, according to mechanisms which appear to be quite different. The principal clinical manifestations express themselves depending on their localization, a pneumothorax in the first case and hemoptysis in the second. One clinical characteristic, however, applies to them all, a rhythm strictly related to periods. The current methods of visualization of the pleura enable a macroscopic diagnosis to occur in the former cases in 64% and the body scanner now localizes the second in all cases. Treatment by Danatrol is often strikingly effective in a few months, notably in the cases with parenchymal localization.

Adult↗

[Evaluation of a screening test for urinary infection].

The interest of using a reagent strip (Multistix-8 SG, Ames, Miles Laboratories) as a screen for urinary tract infection was evaluated in a clinical study involving several sites and 2,183 adult urine specimens of which 340 were infected. The results are expressed in terms of sensitivity, specificity, predictive value of a negative and positive test. The predictive value of a negative test for nitrites in combination with leucocytes (97.5%) justifies the use of the reagent strip in eliminating non-infected urine.

Bacteriological Techniques↗

Autonomic dysfunction in perennial vasomotor rhinitis and the effect of mequitazine.

Thirty patients with perennial vasomotor rhinitis were submitted to pharmacological tests to assess the autonomic responsiveness of extra-nasal and intra-nasal receptors to isoprenaline and phenylephrine by infusion, and to evaluate the effect of 14-days' treatment with mequitazine (5 mg twice daily) and placebo on clinical symptoms and on autonomic sensitivity. Isoprenaline induced a similar tachycardia in all patients, more pronounced than that observed in normal subjects, at the different times of testing, and also an increase in nasal resistance. With phenylephrine, marked bradycardia was observed, reflecting high vagal baroreflex sensitivity, and a transient decrease in nasal resistance was obtained. Mequitazine improved significantly the clinical symptoms but did not modify the autonomic receptivity. It is suggested that in patients with vasomotor rhinitis an autonomic dysfunction may play a role in a predisposing factor in nasal hyperreactivity with non-specific histamine release.

Adolescent↗

A system that facilitates the orientation within procedure nomenclatures through a semantic approach.

The representation of medical concepts should provide the flexibility required to support several purposes. We have implemented a model in which medical terms are represented in a standard format based on a semantic description of the terms. We have focused on the description of procedures. Underlying this project is the assumption that information about medical procedures is crucial in the healthcare system. A prototype has been developed for urology. Because of the large number of terms in the Unified Medical Language System (UMLS) and the abundance of links between them, we have experimented in the use of the UMLS as the foundation for our concept base. We assess the usefulness of this approach and discuss its improvements.

Algorithms↗

Vagal sensitivity in intrinsic and allergic asthma.

In 20 intrinsic and 25 allergic asthmatic patients with active disease, vagal baroreflex sensitivity was assessed by use of the phenylephrine test, and vagal blockade effects on airways were measured by the response to intravenous atropine. For a given phenylephrine-induced increase in blood pressure, bradycardia was more marked in patients with intrinsic asthma than in those with allergic asthma. Intravenous atropine caused a similar spirometric improvement in both groups. It is suggested that: 1) an inverse relationship exists between vagal sensitivity and the allergic state in asthma; 2) antigenic related stimulation modulated by a low vagal tone and non-antigenic related stimuli with high tone modulation result in similar cholinergic discharges.

Adult↗