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Biomedical subjects

D McGuinness

Publications and source records attributed to D McGuinness.

30 records · Page 2Linked to original sources
PubMed1982

Lateral asymmetry: hard or simple-minded?

A letter or a three-dimensional shape was presented in the center of the visual field. Following the off-set of this stimulus either a comparison letter or a three-dimensional shape was flashed briefly in either the right or left visual field. The subject's task was to respond SAME, or DIFFERENT. The stimuli could be in the same plane, rotated in two dimensions (letters) or in three dimensions (three-dimensional shapes). The left visual field presentations (right hemisphere) of same-pair matches for letters only produced faster reaction times and fewer errors. In all other conditions reaction time measures showed no hemisphere effects. By contrast, error score data indicated that the left hemisphere was overwhelmingly more accurate.

Adolescent↗
PubMed1980

A decisional analysis of the effects of inferotemporal lesions in the rhesus monkey.

Modified signal detection procedures were used to analyze the effects of inferotemporal cortical resections. The results demonstrated (a) a severe difficulty in responding to differences in luminance; (b) a severe difficulty in responding to differences in luminance; (b) a small but consistent change in sensitivity (d'), which is attributed to an increased sensitivity to noise or a deficiency in the suppression of irrelevant aspects of the environment; and (c) an enhanced bias to respond to a nonrewarded stimulus (a lowering of criterion). This altered bias contrasts with the results obtained from limbic resections in a previous experiment which produced a marked increase in bias to a rewarded contingency without influencing discrimination or detection.

Animals↗
PubMed1977

The effect of chronic anxiety level upon self control of heart rate.

A sample of 90 subjects were rated on the IPAT anxiety scale and 5 subjects (3 male and 2 female) per group were selected from each of the high and low anxiety categories. All subjects were naive participants in heart rate biofeedback sessions utilising analogue visual feedback. Following a heart rate baseline (no feedback) session, all subjects were required to raise their heart rate and lower their heart rate in two separate trials, a visual "target" criteria being provided. The data collected consisted of a resting baseline heart rate value, mean heart rate increase, and mean heart decrease values expressed as beats per minute. Results indicated a marked ability for highly anxious subjects to self-induce heart rate increases only and for low anxious subjects to decrease their heart rate only.

Anxiety↗
PubMed1976

Away from a unisex psychology: individual differences in visual sensory and perceptual processes.

Four tests of visual perception were given to twenty-five men and twenty-five women. These were a test of acuity, threshold for four field positions, visual persistence, and a measure of comfortable brightness. Subjects also completed five personality questionnaires. In most measures, differences were found to be related to sex rather than to personality factors. In fact, the analyses performed suggest that persenality tests do not measure equivalent processes in men and women. Correlational anaylsis showed all visual functions to be independent of one another with the exception of photopic acuity and scotopic threshold, which were highly correlated. Two new findings on the visual system emerged which have not been reported elsewhere: (i) Four distinct dark adaptation curves were produced, and have been labeled as exponential, flat-exponential, linear, and plateau. All subjects fell into one of these categories and showed a consistent trend to exhibit these curves for all field positions. (ii) Highly significant differences were found in sensitivity for the four visual fields, the upper field was superior, followed by the right, then left, with the lower visual field considerably poorer.

Adolescent↗
PubMed1976

Sex differences in visual persistence: experiments on the Ganzfeld and afterimages.

Sex differences were investigated in two experiments on visual persistence: the Ganzfeld and the afterimage. Males were found to hold visual sensation longer than females, particularly in the Ganzfeld where there was little overlap of scores. Variability of experience in the Ganzfeld was also greater for males and they commonly reported 'blank-out' effects while females did not. There was further evidence from both experiments that females are more responsive to the long-wave region of the frequency spectrum.

Adolescent↗
PubMedDate not supplied

Clinical case definitions for malaria: clinical malaria associated with very low parasite densities in African infants.

In areas endemic for Plasmodium falciparum, clinical malaria is believed to be less common in infants than in older children, but specific case definitions have rarely been determined for this age group. As malaria case definitions are known to be both age- and site-specific, assessment of the risk of disease in infancy requires the development of appropriate diagnostic criteria. In southern Ghana, 154 children were recruited at birth and monitored for fever and malaria infection until 2 years of age. Logistic regression was used to model fever risk as a continuous function of parasite density to determine case definitions for the diagnosis of clinical malaria, and to determine age- and season-specific estimates of the fraction of fevers attributable to malaria (AF); 2360 observations were made on 154 children. For fevers defined by a measured temperature > or = 37.5 degrees C, the estimated population AF was 44% (95% confidence interval 34-53). Estimates of AF varied with age and season. For infants, AF was 51% during the wet season and 22% during the dry season; for children over one year of age, AF was 89% during the wet season and 36% during the dry season. The estimated parasite density threshold for initiation of a febrile episode was 100 parasites per microL of blood in infants, compared with 3500 parasites per microL for children over one year of age. Using these case definitions, the incidence of clinical malaria was estimated at 0.09 cases per child-year at risk for children less than 6 months of age, 0.40 for children aged 6-11 months, and 0.69 for children aged 12-23 months. Of 66 cases of clinical malaria, only 3 were observed in children under 5 months of age. We concluded that, although most fevers in infants are not due to malaria, infant clinical malaria may occur at extremely low parasite densities. This may be indicative of a lack of anti-disease immunity in this age group. In southern Ghana, an infant with axillary temperature > or = 37.5 degrees C and parasitaemia > or = 100/microL should be considered to have clinical malaria. Nevertheless, the incidence of clinical malaria is very low in children under 6 months of age, confirming that they are significantly protected from clinical malaria compared to older children.

Age Factors↗