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D Mehta

Publications and source records attributed to D Mehta.

72 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of alfentanil on hypnotic and antinociceptive components of thiopental sodium anesthesia.

STUDY OBJECTIVE: To determine the effects of alfentanil on the hypnotic and antinociceptive components of thiopental sodium anesthesia. DESIGN: Randomized double-blind study. SETTING: Inpatients at a university-affiliated county hospital. PATIENTS: Eighty unpremedicated ASA physical status I or II female patients aged 18 to 60 years, with a weight range of 50 to 90 kg. INTERVENTIONS: Intravenous injection of thiopental sodium in doses ranging from 1.0 mg/kg to 6.0 mg/kg with or without the addition of alfentanil, 0.01 mg/kg. MEASUREMENTS AND MAIN RESULTS: Dose-response curves were determined for the following three endpoints of anesthesia: eye opening in the response to voice command; eye opening in the response to noxious stimulation induced by pressure on the trapezius muscle; and purposeful movement in the response to the same type of noxious stimulation. The addition of alfentanil, 0.01 mg/kg, markedly decreased thiopental ED50 values for all three endpoints: from 2.6 mg/kg to 1.9 mg/kg (p less than 0.02) for eye opening to voice command, from 3.2 mg/kg to 1.9 mg/kg (p less than 0.0005) for eye opening to noxious pressure, and from 4.2 mg/kg to 2.4 mg/kg (p less than 0.0001) for purposeful movement to noxious pressure. The alfentanil-induced increase in thiopental potency for the antinociceptive effect was greater than that for the hypnotic effect (75% vs 36%, p = 0.02). CONCLUSIONS: Alfentanil strengthened both the hypnotic and antinociceptive components of thiopental anesthesia, although to a different degree: the antinociceptive component more so than the hypnotic, possibly because each component of anesthesia has different underlying mechanisms.

Adult↗
PubMedDate not supplied

Modulation of epidermal growth factor receptors by gamma interferon in a breast cancer cell line.

Interferons (IFNs) may inhibit cell growth via their interaction with growth factors and their receptors. We examined the ability of IFN to modulate Epidermal Growth Factor (EGF) receptor binding in a human breast carcinoma cell line, MDA 468. Gamma interferon and alpha interferon inhibited growth of MDA 468 cells in a dose and time-dependent manner. IFN-gamma and Epidermal Growth Factor (EGF), a known inhibitor of MDA 468 growth, inhibited growth in an additive fashion. Growth inhibition by gamma but not alpha interferon was associated with a decrease in the number of EGF receptors (EGFRs) after 5 days. Scatchard analysis of receptor binding data revealed that gamma but not alpha interferon reduced the number of available EGF receptor binding sites without any change in the affinity of the receptor. IFN significantly affected EGF receptor expression, and the decrease in receptor expression was associated with growth inhibition.

Breast Neoplasms↗
PubMedDate not supplied

Ephedrine as a marker of intravascular injection in laboring parturients.

Thirty healthy laboring parturients were randomly chosen to receive either normal saline (NS), ephedrine 10 mg (EPH-10), or ephedrine 15 mg (EPH-15) intravenously. Changes in maternal heart rate and blood pressure and fetal heart rate were monitored. A clinically useful and statistically significant (less than 0.001) increase in systolic blood pressure of 10 torr or more occurred in all 10 patients in the EPH-15 group. There was no adverse fetal outcome. Transient fetal tachycardia was seen in three fetuses in the EPH-15 group.

Anesthesia, Epidural↗