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Biomedical subjects

D Merten

Publications and source records attributed to D Merten.

14 recordsLinked to original sources

Nonsurgical management of renovascular hypertension in the neonate.

Over an 18-month period nine infants in a neonatal intensive care unit developed hypertension (blood pressure, 115/88 to 280/140 mm Hg) at 2 to 45 days of age. Eight of the nine infants had indwelling umbilical artery catheters prior to onset of hypertension; six of the nine infants had evidence of a patent ductus arteriosus. Peripheral plasma renin activity was greater than 300 ng/ml/3 hr in six of eight infants. Angiograms were abnormal in six of seven infants and computerized renal scans were abnormal in all nine infants. One infant had congenital renal artery stenosis. Eight of nine infants had evidence of unilateral or bilateral renal artery thrombi which were felt to have emanated from an umbilical artery catheter or a ductus arteriosus. Hypertension in all infants was successfully controlled medically (follow-up of 3 to 27 months; mean, 14.4 months). Blood pressures remained normal when medication was discontinued. In our experience, neonatal renovascular hypertension is no longer uncommon, responds to aggressive medical management, and rarely requires early nephrectomy. Neonatal renovascular hypertension was usually associated with umbilical artery catheters positioned above the level of the renal arteries.

Adult

[Radiograph and observation of the development of Q-fever pneumonia (author's transl)].

The radiograph in Q-fever pneumonia and the course of Q-fever was reported with the help of 12 clinically examined cases. Q-fever pneumonia is not to be diffrentiated from viral pneumonia or mycoplasmal pneumonia. A chronic course with residual infiltrates which lasts as long as two or three months is, however, more frequent in Q-fever pneumonia. According to our observations, a correlation seems to exist between the severity of the clinical symptoms, the extent of the pulmonary infiltrate and the level of the titer of the complement fixation.

Antibodies

[False diagnosis of a splenic cyst. A report about arteriography in cystic lesions of the spleen (author's transl)].

A false diagnosis of splenic echinococcal cyst is reported. Angiographic criteria of this misleading lesion are compared with those of three cases with splenic cysts (two were confirmed surgically). Depending on the size of the cyst, spreading and dislocation of branches of splenic arteries as well as definitsmothly outlined parenchymal defects become visible. Surrounding parenchyma may be partially compressed. Calcifications of the cystic wall do not allow differentiation between primary and parasitic cysts. The Casoni test alone is not sufficient as a primary diagnostic tool as it is false positive often. Additional complement binding test for echinococcus is recommended.

Adult

Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation.

Benign pulmonary diseases that have been associated with the accumulation of endogenous lipids within the alveoli, bronchioles, and interstitial tissues include endogenous lipoid pneumonia (ELP), pulmonary alveolar proteinosis (PAP), pulmonary interstitial and intra-alveolar cholesterol granulomas (PICG), various xanthomatous lesions, and malakoplakia. In ELP, fat-filled finely vacuolated macrophages fill the alveoli. In PAP, the aveoli become filled with cholesterol and periodic acid-Schiff (PAS)-positive acellular debris. In PICG, cholesterol esters are released from degenerating macrophages and, as organization occurs, the cholesterol is deposited in the form of acicular clefts within the interstitium. These morphologically distinct presentations of endogenous lipid deposition within the lung have long been thought to represent unique disease processes but several authors now postulate a possible relationship between these entities. We report here on the clinical, radiographic, and morphologic findings in eight pediatric patients with diverse primary disease processes who were subsequently found to have varying and often coexisting degrees of ELP, PAP, and PICG.

Adolescent