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Biomedical subjects

D Mieth

Publications and source records attributed to D Mieth.

30 records · Page 2Linked to original sources
PubMed1984

Antenatal ultrasound diagnosis in cystic adenomatoid malformation of the lung--case report.

Antenatal ultrasound diagnosis of cystic adenomatoid malformation was made in a fetus of 27 weeks gestation. The child was born at term and successfully operated upon 30 hours later. Early recognition by ultrasound allowed for adequate planning and preparation of management between obstetricians, neonatologists , and pediatric surgeons. The present case appears to be the fourth one reported with antenatal ultrasound diagnosis and the first one with successful operation, long-term survival and cure.

Female↗
PubMed1984

EEG spectral power and coherence analysis in healthy full-term neonates.

Continuous, bipolar EEG recording was performed in nineteen healthy full-terms during quiet sleep (Q), REM sleep (R) and wakefulness (W). Spectral power was calculated for the bilateral fronto-central (FC), centro-parietal (CP), parieto-occipital (PO) and temporal (TT) derivations. Coherence was determined for the interhemispheric biFC, biCP, biPO and biTT locations, as well as for the left and right intrahemispheric FC-PO and TT-PO combinations. Power was highest in Q in the CP derivations at 0.4-12/s. Generally, power was higher in Q than in R. In most derivations, Q and R power ran parallel. W power behaviour was different. Up to 8/s, power in W was intermediate between Q and R power. From 10/s, it became highest, particularly in the TT and FC derivations. PO power was low. Highest coherence values occurred in the lowest frequencies. Up to 8/s, biFC, biCP and biPO interhemispheric coherences were highest in R and usually lowest during Q. In the alpha-beta range, highest coherences occurred during Q and lowest during R or W, without much variance between stages. BiPO coherences were remarkably high during all stages. BiTT and intrahemispheric coherences were low and less consistent. These data suggest high synchronization of theta-delta activity between biPO regions, particularly during R. We hypothesize active common generators of neonatal theta-delta activity in the posterior regions, indicating less autonomy and more interdependent behaviour of these areas especially during R.

Cerebral Cortex↗
PubMed1982

Transient EEG patterns during sleep in healthy newborns.

24 healthy full-term newborns underwent polygraphic recordings of EEG, EMG, EOG, ECG, abdominal and thoracic respiration during day-time-sleep. Transient EEG patterns (rhythmic alpha and beta activity, spikes/sharp waves and frontal sharp transients) were visually evaluated and quantified. Rhythmic alpha activity is not very prominent. It is found in all states of sleep and appears only as scattered waves and interrupted sequences. Their duration varies from 1 to 5 sec. Rhythmic beta activity is a feature of quiet and active-REM sleep, repeatedly in spindle-shaped formations. "Typical" sleep spindle activity, however, is very rare. In a few cases rhythmic beta activity also appears in the form of the delta brush pattern. Spikes/sharp waves are sporadic in appearance, non-repetitive in nature and occur mostly multifocal with parietal predominance. They are more frequent in quiet sleep (1 per 2.3 min on average) than in active-REM sleep (1 per 18 min), and were rare in transitional states of sleep (1 per hour). "Frontal sharp transients" show great variations of configuration. They occur most frequently in quiet sleep. Often they appear only unilaterally. Their voltage maximum is frontal, fronto-temporal or praecentral. They are more frequent in REM sleep after wakefulness than after quiet sleep. The individual as well as the sleep-state related frequencies of spike/sharp waves and "frontal sharp transients" tend to differ widely with a range of a factor 10. In some of the newborns these graphoelements are not observed at all during certain sleep phases.

Electroencephalography↗
PubMed1982

[Transcutaneous bilirubin determination in the newborn infant. Recommendations of the Swiss Neonatology Group].

The clinical usefulness of transcutaneous bilirubinometry with the Minolta-Air Shield bilirubinometer was evaluated at four obstetrical neonatology units (Basle, Berne, Lucerne and Zurich). Transcutaneous bilirubin (TcB), expressed as bilirubin index, was compared with simultaneous serum bilirubin estimations in healthy Caucasians babies born at term with a birth weight of more than 2500 g. TcB measured over the forehead: 926 determinations in 629 newborns. TcB measured over the sternum: 404 estimations in 260 newborns. TcB estimations over the sternum produced a closer correlation (r = 0.93) with serum bilirubin than estimations over the forehead (r = 0.81). Mean serum bilirubin value as well as the corresponding 5th and 95th percentiles were calculated for each TcB index. From the data obtained the following practical conclusions can be drawn: TcB estimations are reliable for giving the indication to perform serum bilirubin determinations. In patients with risk factors for kernikterus serum bilirubin should be determined at a TcB index of greater than or equal to 18, in babies without risk factors at a TcB index of greater than or equal to 21.

Bilirubin↗
PubMed1980

Intracranial haemorrhage in the term infant confirmed by computed tomography.

In 8 singleton term infants and 1 postterm infant diagnosis of intracranial haemorrhage (ICH) was clinically established on the 2nd to the 12th day of life and subsequently confirmed by computed tomography (CT). Birth asphyxia was present in 1 infant only. 1 patient died, another developed progressing post-haemorrhagic hydrocephalus requiring a shunt. On follow-up at 2 1/2 to 30 months, psychomotor development was found to be normal in 6 children, mildly delayed in 1 and markedly delayed in another. On comparing our results of ICH in term infants to other published data on both term and preterm infants, we found that in both groups of patients ICH usually occurred within the first 7 days of life and that CT findings were often identical. Mortality rate of preterm babies with ICH was found to be 4.5 times higher than that of term babies while in surviving patients incidence of posthaemorrhagic hydrocephalus was approximately the same. Repeated lumbar punctures were shown to be therapeutically successful in some preterm infants with posthaemorrhagic hydrocephalus. We consider it worth while to use this approach in term infants, too, before placement of a shunt is considered. Etiologic factors and pathogenesis of ICH are briefly discussed at the end of the paper.

Cerebral Hemorrhage↗
PubMed1976

[Congenital cytomegalovirus infection after maternal renal transplantation (author's transl)].

A 34-year-old female gave birth to a 32 to 35 week-old girl one year after she had undergone renal transplantation. The child was dwarfed and microcephalic and also had congenital platelet deficiency and purpura. In addition it was anaemic and suffered from severe neonatal icterus. An initial hypogammaglobulinaemia disappeared except for low IgA levels. The immunoglobulin deficiency is probably correlated with the virologically and serologically proven cytomegalovirus infection. The incidence of this disease seems to be high in children of mothers with renal transplantations.

Agammaglobulinemia↗