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Biomedical subjects

D Miladinović

Publications and source records attributed to D Miladinović.

8 recordsLinked to original sources
PubMed1998

Variation of selenium content in growing wild plants during vegetative period.

There is evidence that selenium (Se) is essential for humans, animals, and some species of microorganisms. This study examines the dynamics of the change of Se accumulation in some growing wild plants: Astragalus onobrychis var. Chlorocarpus (Gris.) Stoj. et Stef. (Leguminosae), Oxytropis pilosa (L.) DC., Salvia officinalis, L., and Simphytum ottomanum L. The influences of some ecological factors (Se content in soil, temperature, and rainfall) have also been surveyed. The Se content of plants from Serbia was 44.5 to 177.0 microg/kg of dry weight. Astragalus onobrychis var. Chlorocarpus (Gris.) Stoj. et Stef. (Leguminosae) accumulates the highest Se content in the blooming stage (161.3 microg/kg). All soils studied were deficient in selenium (< 250 microg/kg). We found a significant correlation between Se content in plants and in the soil (p = 0.88). Rainfall has an influence on Se content in Oxytropis, Salvia, and Simphytum, but not in Astragalus. Our results suggest that Se cannot have a similar role in all plants examined.

Environment↗
PubMed1990

[Methodologic characteristics of the radioreceptor test for insulin on erythrocytes].

Presented, are the results of the characteristics testing of the radioreceptor test for insulin on erythrocytes (precision, reproductiveness and linearity). Our own modification of the method was used. Testing was done on erythrocytes from the same bottle of preserved blood. The following results were received: the used method is precise enough (correlation coefficient from 3-15%), reproductive (correlation coefficient about 15%), and linear (linear correlation coefficient 0.83) in a wide range of erythrocytes. These characteristics allow the use of the applied radioreceptor test in practice.

Erythrocytes↗
PubMed1977

Erythropoietin level and macrocytosis in patients with chronic pulmonary insufficiency.

In 30 patients with respiratory insufficiency due to chronic obstructive pulmonary disease and with normal red blood cell counts, the effect of hypoxia on erythropoiesis was studied. Pronounced hypoxaemia was ascertained in all the patients by measuring PaO2. The calculated HbO2 saturation was less than 85% in group I and greater than 85% in group II, each consisting of 15 patients. Although the RBC counts and Hb concentration were within the limits of normal values, the packed RBC volume was higher than 45% in all the patients tested. The calculated MCV was increased and the erythropoietin level in plasma, indirectly measured in polycythaemic mouse bioassay, was higher than normal. Macrocytosis was shown to be PaO2-dependent and should be, according to Stohlman's data, the result of erythropoietin excess and the subsequent cessation of nucleic acid synthesis with skipped terminal division of erythroblasts in the bone marrow. The absence of erythrocytosis in these patients could be explained by a shortened survival time of macrocytes and/or other causes.

Chronic Disease↗
PubMedDate not supplied

[Personal experience in the diagnosis and therapy of pulmonary thromboembolism].

The analysis of both clinical findings and diagnostic procedures results were performed in 26 patients with thromboembolic pulmonary disease in order to determine the incidence of signs indicating pulmonary thromboembolism. Sudden dyspnea, hemoptysis and chest pains are the most common symptoms of the disease. These symptoms associated with radiographically confirmed pulmonary infiltrations with the elevation of hemidiaphragm and pleural effusion, particularly if they are bilateral, are the main clues for the diagnosis of pulmonary embolism. Perfusion defect on the pulmonary scintigraphy makes this diagnosis almost certain. Hypoxemia and hypocapnia and respiratory alkalosis are frequent findings in thromboembolic pulmonary disease, as well. Fever, increases RBC sedimentation rate and leukocytosis are present in a great deal of patients. In addition, the presence of risk factors related to the development of thrombosis of the lower limbs deep veins, and particularly those related to the long term immobilization as well as diagnostically confirmed venous thrombus are basic guidelines for the diagnostic of pulmonary thromboembolism.

Adult↗
PubMedDate not supplied

[Results of CA-125 tumor marker determination in patients with ovarian carcinoma].

The serum level of tumor marker CA-125 was determined by a specific immunoradiometric assay in 45 healthy persons (control group), in patients with benign ovarian tumors (13), patients with ovarian carcinoma in remission (15) and progression (28), patients with non-ovarian carcinoma (39), patients with benign peritoneal processes (6), and patients with malignant (3) or inflammatory (10) hepatic diseases. A follow-up study was carried out for a few months (4-11) in some patients after the primary therapy for ovarian cancer. The serum levels of CA-125 were always below the border value (30 U/ml) in healthy persons, in patients with benign ovarian tumors (without peritoneal affection), in patients with ovarian cancer in remission, patients with extraovarian cancers without metastases or with extraperitoneal metastases, and in patients with acute viral hepatitis. Patients with the progression of ovarian carcinoma and patients with peritoneal affection (malignant or benign) had elevated CA-125 values. The findings were in a good correlation with the clinical course in the follow-up study.

Adolescent↗
PubMedDate not supplied

[Pulmonary function in persons with kyphoscoliosis].

Pulmonary function in 25 patients with a severe degree of kyphoscoliosis was studied. Severe restrictive ventilatory insufficiency and hypoxaemic-hypercapnic respiratory failure were discovered. Isolated deformities of the vertebral column were diagnosed in 15 patients while ten patients, apart from diagnosed kyphoscoliosis, had associated chronic obstructive pulmonary diseases. Significant differences in pulmonary function impairment between these two groups, i.e. patients with associated chronic obstructive pulmonary disease, were observed. This indicates that associated pulmonary disease accelerates the development and course of respiratory failure. Respiratory blood gas analysis in 11 patients over the course of two years showed significant worsening of hypoxaemia and hypercapnia, which implies that in patients with kyphoscoliosis the disease has a rapid progression once the respiratory failure develops.

Adult↗