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D Milea

Publications and source records attributed to D Milea.

23 records · Page 2Linked to original sources
PubMed1999

Transient acute myopia induced by antilymphocyte globulins.

Acute onset of transient myopia may be induced by several drugs, different mechanisms having been described. We report the occurrence of such an event after intravenous administration of equine antilymphocyte globulins in a patient treated for aplastic anemia. Clinical ocular examination revealed no other abnormality, and ultrasonography disclosed no swelling of the ciliary body. The drug-induced myopia resolved completely after instillation of topical cyclopentolate, suggesting that its mechanism was the occurrence of a ciliary spasm. Acute myopia is a rare event and, to the authors' knowledge, this represents the first case described as being induced by antilymphocyte globulins.

Acute Disease↗
PubMed1999

[Retinopathy in acute pancreatitis].

Acute pancreatitis may involve remote organ systems, including the eye. Funduscopy may reveal in these rare cases presence of a typical ischemic retinopathy, similar to that diagnosed after severe traumas, known as the Purtscher's retinopathy. Pathogenesis of retinopathy in alcoholic retinopathy remains controversial: occurrence of fat embolism or leucothrombosis is discussed in the literature. The outcome of ischemic retinopathy in acute alcoholic pancreatitis is variable. Although there is no specific available treatment, its diagnosis may allow appropriate diagnosis of the causal disease when the general signs are not present.

Acute Disease↗
PubMed1997

[Radiotherapy of macular lesions in age-related macular degeneration (AMD): initial results of a study inducted in Lyon, France].

PURPOSE: To evaluate irradiation effects on functional signs and choroidal neovascular lesions in age-related macular degeneration (AMD) that does not respond to laser therapy. MATERIALS AND METHODS: Since 1994, 250 consecutive AMD patients were treated by two radiotherapy teams for subfoveal neovascular lesions. At the end of September 1996, 52 patients were evaluable with a 1-year follow-up. Group 1 (Département de Radiothérapie Oncologie, Centre Hospitalo-Universitaire Lyon Sud) included 26 patients who were treated with a lateral beam of 6 MV photons. The irradiation doses were 20 Gy in five fractions for small lesions and 28.8 Gy in eight fractions for larger lesions. Group 2 (Centre Oncologie Radiothérapie Saint-Jean) was composed of 26 patients treated with a mini-beam of 25 MV photons via lateral arc-therapy. Beam diameters (14 and 18 mm) were adapted to the lesion size. The total dose was 16 Gy in four fractions or 20 Gy in five fractions. RESULTS: Functional and anatomical results were assessed at 3, 6, 9 months and 1 year after radiation therapy. Stable visual acuity was observed in 44% (23/52) of the patients and visual acuity was improved in 35% (18/52) of the patients at 6 months. Good functional results reached 79% (41/52) at 6 months and 74% (17/23) at 12 months. A significant decrease (> 10%) of the membrane was present in 46% (16/52) of the cases at 6 months and in 65% (15/23) of the cases at 12 months. There was no statistical difference between the two groups and dose levels. All severe complications (1 cataract, 3 dilated choridal vessels, and 2 papillitis) occurred in group 1. CONCLUSION: Though it is too early to conclude on the best dose level, radiotherapy of subfoveal neovascular lesions of AMD that cannot be treated via laser therapy provides encouraging results. The technique used must be very precise to adequately irradiate the fovea and spare surrounding sensitive areas. Further studies and trials involving patients' randomization are necessary to confirm these preliminary results.

Aged↗